Linked Life Data

10433106

Source:http://linkedlifedata.com/resource/pubmed/id/10433106

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-10-4
pubmed:abstractText
The published neurosurgical literature remains unclear as to whether the extent of surgical resection statistically correlates with survival. The possible sources of this current state of confusion and lack of concordance between studies are numerous: different distributions of covariates, different classification criteria, differences in patient selection, and various methodological flaws. Almost all of the modern studies are retrospective and thus subject to numerous sources of bias and variation. Additional retrospective studies and poorly designed prospective studies will not clarify the effect of extent of surgery on survival. In the absence of randomized experiments with well-defined protocols for aggressive and conservative surgery, well-planned and carefully executed prospective observational studies are needed. In the meantime, we are left with the conclusion that little scientifically credible evidence is available to support the assertion that aggressive surgical resection prolongs survival.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0167-594X
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
227-31
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Extent of resection as a prognostic variable in the treatment of gliomas.
pubmed:affiliation
Department of Biomathematics, M.D. Anderson Cancer Center, Houston, TX 77030-4095, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review