Source:http://linkedlifedata.com/resource/pubmed/id/10430664
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0008654,
umls-concept:C0017337,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0029282,
umls-concept:C0036003,
umls-concept:C0205245,
umls-concept:C0208973,
umls-concept:C0439849,
umls-concept:C0443203,
umls-concept:C0445223,
umls-concept:C0615438,
umls-concept:C1517892,
umls-concept:C1552599,
umls-concept:C1704666,
umls-concept:C1704787,
umls-concept:C1705920,
umls-concept:C1708235
|
| pubmed:issue |
8
|
| pubmed:dateCreated |
1999-9-2
|
| pubmed:databankReference | |
| pubmed:abstractText |
S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in the biosynthesis of polyamines. We have previously identified a mouse AdoMetDC gene that exhibits the hallmarks of a retroposon; that is, it has no introns, is flanked by direct repeats, and has a poly(dA) tract at its 3'-end. This gene, termed Amd-2, is not a processed pseudogene; rather, it is transcribed in a variety of mouse tissues and encodes a functional enzyme. In the current report, we present the sequence of a 6.7-kb genomic segment of the Amd-2 locus. Several sequences of interest, including an intercisternal A particle (IAP) element, a transposon-related sequence, and several expressed sequence tags (ESTs), were found within or near Amd-2. We also show, through analysis of an interspecific backcross, that Amd-2 is located on Chr 12, tightly linked to the gene (Odc) that encodes ornithine decarboxylase, another key enzyme in polyamine synthesis. Finally, we show that Amd-2 is present among several divergent species of the genus Mus. Thus, the integration event that generated Amd-2 may have occurred early during Mus evolution.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0938-8990
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
784-8
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:10430664-Adenosylmethionine Decarboxylase,
pubmed-meshheading:10430664-Animals,
pubmed-meshheading:10430664-Biological Evolution,
pubmed-meshheading:10430664-Chromosome Mapping,
pubmed-meshheading:10430664-Crosses, Genetic,
pubmed-meshheading:10430664-DNA,
pubmed-meshheading:10430664-Genetic Linkage,
pubmed-meshheading:10430664-Introns,
pubmed-meshheading:10430664-Mice,
pubmed-meshheading:10430664-Mice, Inbred C57BL,
pubmed-meshheading:10430664-Molecular Sequence Data,
pubmed-meshheading:10430664-Muridae,
pubmed-meshheading:10430664-Ornithine Decarboxylase,
pubmed-meshheading:10430664-Phylogeny,
pubmed-meshheading:10430664-Species Specificity
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
The functional intronless S-adenosylmethionine decarboxylase gene of the mouse (Amd-2) is linked to the ornithine decarboxylase gene (Odc) on chromosome 12 and is present in distantly related species of the genus Mus.
|
| pubmed:affiliation |
Department of Cellular and Developmental Biology, Umeâ University, S-901 87 Umeâ, Sweden.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|