Source:http://linkedlifedata.com/resource/pubmed/id/10430270
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1999-8-31
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| pubmed:abstractText |
Matrix metalloproteinases (MMPs) have been implicated in the invasion and metastasis of tumor cells. To elucidate the involvement of MMP-1 in human pancreatic ductal adenocarcinoma, we performed immunohistochemical analysis on tissues from 2 fetal pancreases, 5 normal pancreases, 6 cases of chronic pancreatitis, and 46 pancreatic ductal adenocarcinomas. In addition, among the pancreatic carcinomas, we compared MMP-1 expression in relation to the degree of differentiation, lymph node metastasis, and depth of invasion of the carcinoma. MMP-1 was expressed faintly in fetal and normal pancreatic tissues. Among the 46 pancreatic carcinomas, 33 (72%) showed positive staining for the MMP-1 protein. There was no difference in the degree of differentiation. In situ hybridization confirmed the presence of MMP-1 mRNA in the pancreatic carcinomas. Expression of MMP-1 mRNA was also detected in two human pancreatic carcinoma cell lines and three pancreatic carcinoma tissues by the reverse transcription polymerase chain reaction method. MMP-1 was expressed in the carcinoma cells themselves and in stromal fibroblasts. Patients with MMP-1 positivity in the primary site had a significantly poorer prognosis than patients who were MMP-1 negative (P < .05). MMP-1 expression, however, had no relation to the presence of lymph node metastasis, tumor size, or tumor-node-metastasis stage in pancreatic carcinomas. These findings suggest that MMP-1 expression is related to the carcinogenesis and prognosis of human pancreatic ductal adenocarcinoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
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| pubmed:issn |
0893-3952
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
12
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
669-74
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10430270-Adenocarcinoma,
pubmed-meshheading:10430270-Aged,
pubmed-meshheading:10430270-Aged, 80 and over,
pubmed-meshheading:10430270-Collagenases,
pubmed-meshheading:10430270-Female,
pubmed-meshheading:10430270-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10430270-Humans,
pubmed-meshheading:10430270-Immunohistochemistry,
pubmed-meshheading:10430270-In Situ Hybridization,
pubmed-meshheading:10430270-Male,
pubmed-meshheading:10430270-Matrix Metalloproteinase 1,
pubmed-meshheading:10430270-Middle Aged,
pubmed-meshheading:10430270-Pancreas,
pubmed-meshheading:10430270-Pancreatic Ducts,
pubmed-meshheading:10430270-Pancreatic Neoplasms,
pubmed-meshheading:10430270-Prognosis,
pubmed-meshheading:10430270-RNA,
pubmed-meshheading:10430270-Reverse Transcriptase Polymerase Chain Reaction
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Expression of the MMP-1 in human pancreatic carcinoma: relationship with prognostic factor.
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| pubmed:affiliation |
Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Japan.
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| pubmed:publicationType |
Journal Article
|