Linked Life Data

10430220

Source:http://linkedlifedata.com/resource/pubmed/id/10430220

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-8-24
pubmed:abstractText
Human herpesvirus type 8 (HHV-8) is a recently identified gamma herpesvirus that is associated with and most likely the etiologic agent of Kaposi's sarcoma (KS). Both monocytes and B lymphocytes appear to serve as reservoirs for HHV-8 in asymptomatic individuals, whereas HHV-8 is present in both spindle cells and microvascular endothelial cells within KS lesions. This suggests that a necessary event for the development of KS is infection of endothelial cells with HHV-8. This paper proposes a model for KS in which cellular adhesion molecules are involved in the recruitment of HHV-8-infected leukocytes into KS-prone areas and in which HHV-8-infected cells overcome the antiviral machinery present in endothelial cells. Mechanisms employed by endothelial cells to recognize and contain viral infections are discussed and possible mechanisms employed by HHV-8 to overcome the endothelial antiviral response.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1525-4135
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
21 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S58-65
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Consideration of host-viral interactions in the pathogenesis of Kaposi's sarcoma.
pubmed:affiliation
Winship Cancer Center, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA. mofferm@emory.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review