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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-8-24
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pubmed:abstractText |
We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-beta expression in CD25+44- thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-beta expression can be accounted for by pre-TCR-dependent signal mediation, putting into question the function of a putative pro-TCR.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-10097132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-1547487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-7596413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-7831294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-7947468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-8149963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-8293460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-8382254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-8608942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-9143695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-9143699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-9390684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-9419216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-9802979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10429678-9846486
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/pre-T cell receptor alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
141-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10429678-Animals,
pubmed-meshheading:10429678-Antigens, CD3,
pubmed-meshheading:10429678-Antigens, CD4,
pubmed-meshheading:10429678-Antigens, CD8,
pubmed-meshheading:10429678-Gene Expression Regulation,
pubmed-meshheading:10429678-Membrane Glycoproteins,
pubmed-meshheading:10429678-Mice,
pubmed-meshheading:10429678-Mice, Inbred C57BL,
pubmed-meshheading:10429678-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10429678-Receptors, Interleukin-2,
pubmed-meshheading:10429678-T-Lymphocytes
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pubmed:year |
1999
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pubmed:articleTitle |
Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex.
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pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale (INSERM) U373, Hôpital Necker-Enfants Malades, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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