Source:http://linkedlifedata.com/resource/pubmed/id/10428828
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
32
|
| pubmed:dateCreated |
1999-9-2
|
| pubmed:abstractText |
Type 2 diabetes is characterized by decreased rates of insulin-stimulated glucose uptake and utilization, reduced hexokinase II mRNA and enzyme production, and low basal levels of glucose 6-phosphate in insulin-sensitive skeletal muscle and adipose tissues. Hexokinase II is primarily expressed in muscle and adipose tissues where it catalyzes the phosphorylation of glucose to glucose 6-phosphate, a possible rate-limiting step for glucose disposal. To investigate the role of hexokinase II in insulin action and in glucose homeostasis as well as in mouse development, we generated a hexokinase II knock-out mouse. Mice homozygous for hexokinase II deficiency (HKII(-/-)) died at approximately 7.5 days post-fertilization, indicating that hexokinase II is vital for mouse embryogenesis after implantation and before organogenesis. HKII(+/-) mice were viable, fertile, and grew normally. Surprisingly, even though HKII(+/-) mice had significantly reduced (by 50%) hexokinase II mRNA and activity levels in skeletal muscle, heart, and adipose tissue, they did not exhibit impaired insulin action or glucose tolerance even when challenged with a high-fat diet.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0021-9258
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
274
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
22517-23
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10428828-Adipose Tissue,
pubmed-meshheading:10428828-Animals,
pubmed-meshheading:10428828-Chimera,
pubmed-meshheading:10428828-Dietary Fats,
pubmed-meshheading:10428828-Female,
pubmed-meshheading:10428828-Fertility,
pubmed-meshheading:10428828-Fetal Death,
pubmed-meshheading:10428828-Genes, Lethal,
pubmed-meshheading:10428828-Glucose,
pubmed-meshheading:10428828-Glucose Tolerance Test,
pubmed-meshheading:10428828-Heterozygote,
pubmed-meshheading:10428828-Hexokinase,
pubmed-meshheading:10428828-Homozygote,
pubmed-meshheading:10428828-Insulin,
pubmed-meshheading:10428828-Insulin Resistance,
pubmed-meshheading:10428828-Male,
pubmed-meshheading:10428828-Mice,
pubmed-meshheading:10428828-Mice, Mutant Strains,
pubmed-meshheading:10428828-Muscle, Skeletal,
pubmed-meshheading:10428828-Pregnancy,
pubmed-meshheading:10428828-Stem Cells
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
|
| pubmed:affiliation |
Department of Medicine, University of Kuopio, FIN-70211 Kuopio, Finland.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|