|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0008947,
umls-concept:C0008976,
umls-concept:C0021149,
umls-concept:C0034897,
umls-concept:C0035647,
umls-concept:C0042238,
umls-concept:C0043210,
umls-concept:C0151526,
umls-concept:C0205217,
umls-concept:C0205359,
umls-concept:C0355642,
umls-concept:C0392756,
umls-concept:C0445202,
umls-concept:C0677582
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1999-9-21
|
|
pubmed:abstractText |
To test the hypothesis that prophylactic administration of clindamycin 2% vaginal cream can reduce the incidence of preterm birth in a high risk population.
|
|
pubmed:commentsCorrections |
|
|
pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/ANTIBIOTICS,
http://linkedlifedata.com/resource/pubmed/keyword/DRUGS,
http://linkedlifedata.com/resource/pubmed/keyword/Demographic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Double-blind Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Europe,
http://linkedlifedata.com/resource/pubmed/keyword/NETHERLANDS,
http://linkedlifedata.com/resource/pubmed/keyword/Population,
http://linkedlifedata.com/resource/pubmed/keyword/Population Characteristics,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy Outcomes,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnant Women,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Treatment,
http://linkedlifedata.com/resource/pubmed/keyword/Western Europe
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0306-5456
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
106
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
652-7
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:otherAbstract |
PIP: This multi-center, randomized, double-blind, placebo-controlled trial aimed to determine whether prophylactic administration of clindamycin 2% vaginal cream can reduce the incidence of preterm birth in a high risk population. A total of 168 eligible women attending the antenatal clinics of 12 hospitals in Netherlands participated in the study. Clindamycin 2% vaginal cream was administered to 83 women, and placebo cream to 85 women, daily for 7 days at 26 and 32 weeks of gestation. Results of the study showed no difference in the overall preterm birth between clindamycin (23%) and placebo (18%) in the intention-to-treat analysis. In the subgroup, which completed the trial and administered all medication, more women delivered before 34 weeks in the clindamycin group (9%) compared to the placebo group (1.4%). Moreover, occurrence of neonatal infectious morbidity was higher in the clindamycin group (5/83 vs. 0/85; P 0.05). In conclusion, clindamycin 2% vaginal cream given prophylactically to women with a spontaneous preterm birth in the preceding pregnancy did not prevent preterm delivery or reduce the number of admissions for threatened preterm labor.
|
|
pubmed:meshHeading |
pubmed-meshheading:10428520-Adult,
pubmed-meshheading:10428520-Anti-Bacterial Agents,
pubmed-meshheading:10428520-Clindamycin,
pubmed-meshheading:10428520-Double-Blind Method,
pubmed-meshheading:10428520-Female,
pubmed-meshheading:10428520-Humans,
pubmed-meshheading:10428520-Obstetric Labor, Premature,
pubmed-meshheading:10428520-Pregnancy,
pubmed-meshheading:10428520-Pregnancy Complications, Infectious,
pubmed-meshheading:10428520-Risk Factors,
pubmed-meshheading:10428520-Vaginal Creams, Foams, and Jellies
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Prophylactic administration of clindamycin 2% vaginal cream to reduce the incidence of spontaneous preterm birth in women with an increased recurrence risk: a randomised placebo-controlled double-blind trial.
|
|
pubmed:affiliation |
Department of Obstetrics and Gynaecology, Diaconessenhuis Meppel, The Netherlands.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
