Linked Life Data

10423646

Source:http://linkedlifedata.com/resource/pubmed/id/10423646

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-12-16
pubmed:abstractText
The purpose of this study was to compare the efficacy of three dosages of potassium-magnesium citrate in overcoming thiazide-induced hypokalemia and magnesium loss and increasing urinary pH and citrate. Sixty-one normal subjects first took hydrochlorothiazide at 50 mg/d. After 3 weeks of thiazide treatment or earlier if hypokalemia developed, the subjects were randomized to take one of three dosages of potassium-magnesium citrate (K ( 4 ) MgCit ( 2 ) ) for 3 weeks while continuing on the thiazide: 4 tablets per day (24 mEq potassium, 12 mEq magnesium, and 36 mEq citrate per day), 7 tablets per day (49 mEq potassium, 24.5 mEq magnesium, and 73.5 mEq citrate per day), or 10 tablets per day (70 mEq potassium, 35 mEq magnesium, and 105 mEq citrate per day). Outcome measures were changes in serum potassium and magnesium and urinary potassium, magnesium, pH, and citrate. All three dosages of potassium-magnesium citrate significantly increased serum potassium concentration, with >80% of subjects regaining normal values despite continued thiazide therapy. The two higher dosages, but not the lowest dosage, caused a small but significant increase in serum magnesium concentration, while substantially increasing urinary magnesium. All three dosages significantly increased urinary pH and citrate in a dose-dependent manner. The lowest dosage produced increases sufficient to prevent stone recurrence. Side effects of thiazide therapy were ameliorated by the highest dosage but not by the two lower dosages. Potassium-magnesium citrate at a dosage of 4 tablets per day is adequate to correct thiazide-induced hypokalemia and to increase urinary pH and citrate sufficiently for stone prevention. Higher dosages are probably required for the prevention of magnesium loss and adverse symptoms of thiazide therapy.
pubmed:grant
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1075-2765
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-50
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10423646-Adult, pubmed-meshheading:10423646-Benzothiadiazines, pubmed-meshheading:10423646-Citrates, pubmed-meshheading:10423646-Citric Acid, pubmed-meshheading:10423646-Diuretics, pubmed-meshheading:10423646-Dose-Response Relationship, Drug, pubmed-meshheading:10423646-Drug Combinations, pubmed-meshheading:10423646-Female, pubmed-meshheading:10423646-Humans, pubmed-meshheading:10423646-Hydrogen-Ion Concentration, pubmed-meshheading:10423646-Hypokalemia, pubmed-meshheading:10423646-Kidney Calculi, pubmed-meshheading:10423646-Magnesium, pubmed-meshheading:10423646-Magnesium Compounds, pubmed-meshheading:10423646-Magnesium Deficiency, pubmed-meshheading:10423646-Male, pubmed-meshheading:10423646-Potassium, pubmed-meshheading:10423646-Potassium Compounds, pubmed-meshheading:10423646-Random Allocation, pubmed-meshheading:10423646-Recurrence, pubmed-meshheading:10423646-Sodium Chloride Symporter Inhibitors, pubmed-meshheading:10423646-Time Factors
pubmed:year
1999
pubmed:articleTitle
Effect of varying doses of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
pubmed:affiliation
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial, Research Support, Non-U.S. Gov't