| pubmed-article:10421406 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10421406 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:10421406 | lifeskim:mentions | umls-concept:C0206679 | lld:lifeskim |
| pubmed-article:10421406 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:10421406 | lifeskim:mentions | umls-concept:C0004793 | lld:lifeskim |
| pubmed-article:10421406 | lifeskim:mentions | umls-concept:C0043194 | lld:lifeskim |
| pubmed-article:10421406 | lifeskim:mentions | umls-concept:C1336633 | lld:lifeskim |
| pubmed-article:10421406 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:10421406 | lifeskim:mentions | umls-concept:C1705294 | lld:lifeskim |
| pubmed-article:10421406 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:10421406 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10421406 | pubmed:dateCreated | 1999-8-31 | lld:pubmed |
| pubmed-article:10421406 | pubmed:abstractText | Recurrent acyclovir (ACV)-resistant (ACV-r) herpes simplex virus type 1 (HSV-1) infections occurred in a patient with Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency syndrome composed of three clinical characteristics of immunodeficiency, thrombocytopenia, and an eczematous dermatitis. The patient had severe and recurrent ACV-r herpes simplex and was treated with vidarabine in a satisfactory manner from 1993 to 1997. During the 4-year observation period, two ACV-sensitive (ACV-s) HSV-1 isolates and five ACV-r HSV-1 isolates were recovered. The nucleotide sequence of the thymidine kinase (TK) gene from these sequential ACV-r isolates was compared with the ACV-s isolates. A single nucleotide deletion of cytosine (C) from homopolymer stretch of four C residues between nucleotide 1061 and 1064 of the open reading frame was found in all ACV-r isolates. No other differences were observed in the TK nucleotide sequence between ACV-s and ACV-r isolates. The TK nucleotide sequences of the two ACV-s isolates were identical to each other and those of the five ACV-r isolates were identical to one another. These results suggest that the ACV-r HSV-1 might have derived from the ACV-s strain in the patient body and that TK-associated ACV-r HSV-1 can reactivate from latency. | lld:pubmed |
| pubmed-article:10421406 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10421406 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10421406 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10421406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10421406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10421406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10421406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10421406 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10421406 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10421406 | pubmed:issn | 0146-6615 | lld:pubmed |
| pubmed-article:10421406 | pubmed:author | pubmed-author:MizutaKK | lld:pubmed |
| pubmed-article:10421406 | pubmed:author | pubmed-author:SaikiTT | lld:pubmed |
| pubmed-article:10421406 | pubmed:author | pubmed-author:ItohKK | lld:pubmed |
| pubmed-article:10421406 | pubmed:author | pubmed-author:MorikawaSS | lld:pubmed |
| pubmed-article:10421406 | pubmed:author | pubmed-author:HiranoYY | lld:pubmed |
| pubmed-article:10421406 | pubmed:author | pubmed-author:SuzutaniTT | lld:pubmed |
| pubmed-article:10421406 | pubmed:author | pubmed-author:NagamineMM | lld:pubmed |
| pubmed-article:10421406 | pubmed:author | pubmed-author:MuronoKK | lld:pubmed |
| pubmed-article:10421406 | pubmed:author | pubmed-author:NiikuraMM | lld:pubmed |
| pubmed-article:10421406 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10421406 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:10421406 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10421406 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10421406 | pubmed:pagination | 387-93 | lld:pubmed |
| pubmed-article:10421406 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:meshHeading | pubmed-meshheading:10421406... | lld:pubmed |
| pubmed-article:10421406 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10421406 | pubmed:articleTitle | Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-resistant herpes simplex virus. | lld:pubmed |
| pubmed-article:10421406 | pubmed:affiliation | Department of Pediatrics, Asahikawa Medical College, Hokkaido, Japan. msaijo@nih.go.jp | lld:pubmed |
| pubmed-article:10421406 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10421406 | pubmed:publicationType | Case Reports | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10421406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10421406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10421406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10421406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10421406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10421406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10421406 | lld:pubmed |
