Source:http://linkedlifedata.com/resource/pubmed/id/10421406
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1999-8-31
|
| pubmed:abstractText |
Recurrent acyclovir (ACV)-resistant (ACV-r) herpes simplex virus type 1 (HSV-1) infections occurred in a patient with Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency syndrome composed of three clinical characteristics of immunodeficiency, thrombocytopenia, and an eczematous dermatitis. The patient had severe and recurrent ACV-r herpes simplex and was treated with vidarabine in a satisfactory manner from 1993 to 1997. During the 4-year observation period, two ACV-sensitive (ACV-s) HSV-1 isolates and five ACV-r HSV-1 isolates were recovered. The nucleotide sequence of the thymidine kinase (TK) gene from these sequential ACV-r isolates was compared with the ACV-s isolates. A single nucleotide deletion of cytosine (C) from homopolymer stretch of four C residues between nucleotide 1061 and 1064 of the open reading frame was found in all ACV-r isolates. No other differences were observed in the TK nucleotide sequence between ACV-s and ACV-r isolates. The TK nucleotide sequences of the two ACV-s isolates were identical to each other and those of the five ACV-r isolates were identical to one another. These results suggest that the ACV-r HSV-1 might have derived from the ACV-s strain in the patient body and that TK-associated ACV-r HSV-1 can reactivate from latency.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0146-6615
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
58
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
387-93
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10421406-Acyclovir,
pubmed-meshheading:10421406-Amino Acid Sequence,
pubmed-meshheading:10421406-Antiviral Agents,
pubmed-meshheading:10421406-Base Sequence,
pubmed-meshheading:10421406-Child,
pubmed-meshheading:10421406-DNA, Viral,
pubmed-meshheading:10421406-Drug Resistance, Microbial,
pubmed-meshheading:10421406-Follow-Up Studies,
pubmed-meshheading:10421406-Genetic Variation,
pubmed-meshheading:10421406-Herpes Simplex,
pubmed-meshheading:10421406-Herpesvirus 1, Human,
pubmed-meshheading:10421406-Humans,
pubmed-meshheading:10421406-Japan,
pubmed-meshheading:10421406-Male,
pubmed-meshheading:10421406-Microbial Sensitivity Tests,
pubmed-meshheading:10421406-Molecular Sequence Data,
pubmed-meshheading:10421406-Phosphorylation,
pubmed-meshheading:10421406-Sequence Analysis, DNA,
pubmed-meshheading:10421406-Sequence Homology, Amino Acid,
pubmed-meshheading:10421406-Thymidine Kinase,
pubmed-meshheading:10421406-Wiskott-Aldrich Syndrome
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-resistant herpes simplex virus.
|
| pubmed:affiliation |
Department of Pediatrics, Asahikawa Medical College, Hokkaido, Japan. msaijo@nih.go.jp
|
| pubmed:publicationType |
Journal Article,
Case Reports
|