Linked Life Data

10421223

Source:http://linkedlifedata.com/resource/pubmed/id/10421223

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1999-8-3
pubmed:abstractText
This study evaluated endothelin production by endothelial cells after exposure to nicotine or caffeine. Vasoconstrictive properties have been attributed to both nicotine and caffeine. The presence of endothelin, a potent vasoconstrictor itself, was determined using a radioimmunoassay. The optimal stimulatory doses for nicotine and caffeine were determined to be 1.0 micromol/L and 1.0 mmol/L, respectively. When endothelin production was evaluated over time after exposure to the optimal dose of each agent, it was determined that nicotine stimulated maximum endothelin production within 5 minutes. Caffeine failed to cause a distinct peak of endothelin production within 20 minutes. These results suggest that nicotine may have a possible acute and short-lived effect on the vasoconstrictive response associated with endothelin, while caffeine-induced endothelin release may require more long-term exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0026-0495
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
845-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Production of endothelin by cultured human endothelial cells following exposure to nicotine or caffeine.
pubmed:affiliation
Department of Biology, Middle Tennessee State University, Murfreesboro 37132, USA.
pubmed:publicationType
Journal Article