| pubmed-article:10419650 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10419650 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:10419650 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:10419650 | lifeskim:mentions | umls-concept:C0232478 | lld:lifeskim |
| pubmed-article:10419650 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10419650 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10419650 | pubmed:dateCreated | 1999-8-12 | lld:pubmed |
| pubmed-article:10419650 | pubmed:abstractText | We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We examined the relative levels of the Mx mRNA signal using semiquantitative reverse transcription-polymerase chain reaction analysis on splenocytes from mice and peripheral blood mononuclear cells from man after IFN-alpha ingestion. Both mice and man demonstrated inducible levels of Mx mRNA after ingesting IFN-alpha. Murine spleen T cells and CD8(+)T cells also demonstrated upregulation of Mx mRNA. Murine whole splenocytes demonstrated upregulation of Mx mRNA after IFN-alpha ingestion of 10 and 100 U, but not after 0, 1000, 5000 U. Ingested IFN-alpha acts via established pathways of type 1 IFN signalling. | lld:pubmed |
| pubmed-article:10419650 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10419650 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10419650 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10419650 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10419650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10419650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10419650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10419650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10419650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10419650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10419650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10419650 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10419650 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10419650 | pubmed:issn | 1043-4666 | lld:pubmed |
| pubmed-article:10419650 | pubmed:author | pubmed-author:NelsonLL | lld:pubmed |
| pubmed-article:10419650 | pubmed:author | pubmed-author:WolinskyJ SJS | lld:pubmed |
| pubmed-article:10419650 | pubmed:author | pubmed-author:BrodS ASA | lld:pubmed |
| pubmed-article:10419650 | pubmed:author | pubmed-author:JinRR | lld:pubmed |
| pubmed-article:10419650 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
| pubmed-article:10419650 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10419650 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:10419650 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10419650 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10419650 | pubmed:pagination | 492-9 | lld:pubmed |
| pubmed-article:10419650 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:10419650 | pubmed:meshHeading | pubmed-meshheading:10419650... | lld:pubmed |
| pubmed-article:10419650 | pubmed:meshHeading | pubmed-meshheading:10419650... | lld:pubmed |
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| pubmed-article:10419650 | pubmed:meshHeading | pubmed-meshheading:10419650... | lld:pubmed |
| pubmed-article:10419650 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10419650 | pubmed:articleTitle | Ingested interferon alpha induces Mx mRNA. | lld:pubmed |
| pubmed-article:10419650 | pubmed:affiliation | Department of Neurology and Graduate School of Biomedical Sciences, University of Texas-Houston, Houston, TX 77225, USA. sbrod@neuro.med.uth.tmc.edu | lld:pubmed |
| pubmed-article:10419650 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10419650 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10419650 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10419650 | lld:pubmed |
