|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1999-8-12
|
|
pubmed:abstractText |
We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We examined the relative levels of the Mx mRNA signal using semiquantitative reverse transcription-polymerase chain reaction analysis on splenocytes from mice and peripheral blood mononuclear cells from man after IFN-alpha ingestion. Both mice and man demonstrated inducible levels of Mx mRNA after ingesting IFN-alpha. Murine spleen T cells and CD8(+)T cells also demonstrated upregulation of Mx mRNA. Murine whole splenocytes demonstrated upregulation of Mx mRNA after IFN-alpha ingestion of 10 and 100 U, but not after 0, 1000, 5000 U. Ingested IFN-alpha acts via established pathways of type 1 IFN signalling.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1043-4666
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 1999 Academic Press.
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
492-9
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10419650-Administration, Oral,
pubmed-meshheading:10419650-Animals,
pubmed-meshheading:10419650-Antiviral Agents,
pubmed-meshheading:10419650-Densitometry,
pubmed-meshheading:10419650-Dose-Response Relationship, Drug,
pubmed-meshheading:10419650-Female,
pubmed-meshheading:10419650-GTP-Binding Proteins,
pubmed-meshheading:10419650-Humans,
pubmed-meshheading:10419650-Immunologic Factors,
pubmed-meshheading:10419650-Interferon-alpha,
pubmed-meshheading:10419650-Male,
pubmed-meshheading:10419650-Mice,
pubmed-meshheading:10419650-Proteins,
pubmed-meshheading:10419650-RNA, Messenger,
pubmed-meshheading:10419650-Spleen
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Ingested interferon alpha induces Mx mRNA.
|
|
pubmed:affiliation |
Department of Neurology and Graduate School of Biomedical Sciences, University of Texas-Houston, Houston, TX 77225, USA. sbrod@neuro.med.uth.tmc.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
