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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-9-24
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pubmed:abstractText |
The effect of barium (1 mM) on a delayed rectifier-type potassium current was examined in bullfrog sympathetic neurons. An M-type potassium current was eliminated by pretreatment of the cells with a microbial product, wortmannin (10 microM). An A-type potassium current was continuously inactivated by setting a holding potential at -65 mV. In treated cells (n = 10), the delayed rectifier at 0 mV averaged 2200 +/- 107 pA in the presence of barium (1 mM) as compared to 2308 +/- 110 pA in the controls, and 2085 +/- 103 pA after washing out the barium. It is concluded that the delayed rectifier is insensitive to barium blockage in amphibian autonomic neurons.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0385-0005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10418723-Androstadienes,
pubmed-meshheading:10418723-Animals,
pubmed-meshheading:10418723-Barium,
pubmed-meshheading:10418723-Cells, Cultured,
pubmed-meshheading:10418723-Delayed Rectifier Potassium Channels,
pubmed-meshheading:10418723-Ganglia, Sympathetic,
pubmed-meshheading:10418723-Potassium Channel Blockers,
pubmed-meshheading:10418723-Potassium Channels,
pubmed-meshheading:10418723-Potassium Channels, Voltage-Gated,
pubmed-meshheading:10418723-Rana catesbeiana
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pubmed:year |
1998
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pubmed:articleTitle |
Effects of barium on delayed rectifier potassium current in bullfrog sympathetic neurons pretreated with wortmannin.
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pubmed:affiliation |
Department of Physiology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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