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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-10-27
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pubmed:abstractText |
Examination of the expression pattern of the winged-helix transcription factor BF-1 outside of the neural tube in mouse embryos suggests that BF-1 is restricted to a population of cells that gives rise to the ectodermal placodes and their derivatives. Within the sensory cranial nerve ganglia, the expression of BF-1 distinguishes cells that arise from the placodes from those derived from the neural crest. Expression of a lacZ transgene targeted to the BF-1 locus was used to follow the placodal lineage during mouse development. Analysis of placodal development in mice with a targeted deletion of BF-1 reveals that, although BF-1 is required for proliferation of the cells arising from the nasal placode, it is not required for the proliferation, survival, or both, of placode-derived cells in the sensory cranial nerve ganglia. Dev Dyn 1999;215:332-343.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1058-8388
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
215
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
332-43
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10417822-Animals,
pubmed-meshheading:10417822-Cell Lineage,
pubmed-meshheading:10417822-Cell Movement,
pubmed-meshheading:10417822-Chick Embryo,
pubmed-meshheading:10417822-DNA-Binding Proteins,
pubmed-meshheading:10417822-Early Growth Response Protein 2,
pubmed-meshheading:10417822-Ectoderm,
pubmed-meshheading:10417822-Embryo, Mammalian,
pubmed-meshheading:10417822-Embryo, Nonmammalian,
pubmed-meshheading:10417822-Forkhead Transcription Factors,
pubmed-meshheading:10417822-Ganglia, Sensory,
pubmed-meshheading:10417822-Gene Expression Regulation, Developmental,
pubmed-meshheading:10417822-In Situ Hybridization,
pubmed-meshheading:10417822-Mice,
pubmed-meshheading:10417822-Mice, Inbred CBA,
pubmed-meshheading:10417822-Mice, Transgenic,
pubmed-meshheading:10417822-Nerve Tissue Proteins,
pubmed-meshheading:10417822-Time Factors,
pubmed-meshheading:10417822-Transcription Factors
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pubmed:year |
1999
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pubmed:articleTitle |
Dynamics of placodal lineage development revealed by targeted transgene expression.
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pubmed:affiliation |
Cell Biology Program, Sloan-Kettering Division, Cornell University Graduate School of Medical Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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