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pubmed-article:10417255pubmed:abstractTextDiffusion tensor imaging is a magnetic resonance method which provides quantitative measurements of the directionality (anisotropy) of diffusion. Anisotropy measurements can be used to obtain quantitative information about the microstructural integrity of white matter tracts. In intact tracts diffusion is restricted and directional because water molecules move predominantly longitudinally to tracts. The aim of this study was to measure the anisotropy of diffusion in patients with chronic hemiparesis. We measured in the corona radiata and the cerebral peduncle in 10 patients with a chronic hemiparesis and supratentorial lesions and 10 control subjects in regions of interest. In all patients anisotropy was reduced in the coronal radiata contralateral to the hemiparesis by more than 3 SD compared to control subjects. In three patients, each of which had a severe hemiparesis, anisotropy in the cerebral peduncle was reduced by more than 3 SD compared to normal control subjects. Our findings suggest that reduced anisotropy is associated with chronic hemiparesis.lld:pubmed
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pubmed-article:10417255pubmed:authorpubmed-author:FranconiFFlld:pubmed
pubmed-article:10417255pubmed:authorpubmed-author:ShorvonS DSDlld:pubmed
pubmed-article:10417255pubmed:authorpubmed-author:ClarkC ACAlld:pubmed
pubmed-article:10417255pubmed:authorpubmed-author:BarkerG JGJlld:pubmed
pubmed-article:10417255pubmed:authorpubmed-author:WieshmannU...lld:pubmed
pubmed-article:10417255pubmed:authorpubmed-author:SymmsM RMRlld:pubmed
pubmed-article:10417255pubmed:copyrightInfoCopyright 1999 Academic Press.lld:pubmed
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pubmed-article:10417255pubmed:volume10lld:pubmed
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pubmed-article:10417255pubmed:pagination225-30lld:pubmed
pubmed-article:10417255pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10417255pubmed:year1999lld:pubmed
pubmed-article:10417255pubmed:articleTitleAnisotropy of water diffusion in corona radiata and cerebral peduncle in patients with hemiparesis.lld:pubmed
pubmed-article:10417255pubmed:affiliationInstitute of Neurology, University College London, London, WC1N 3BG, United Kingdom.lld:pubmed
pubmed-article:10417255pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10417255pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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