Linked Life Data

10415424

Source:http://linkedlifedata.com/resource/pubmed/id/10415424

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1999-10-15
pubmed:abstractText
Potential anxiolytic-like properties of intracerebroventricular (i.c. v.) infusion of orphanin FQ (OFQ), a recently discovered neuropeptide, were investigated in the mouse defense test battery, a well-validated anxiolytic screening test. In this model, Swiss mice are directly confronted with a natural threat (a rat) as well as situations associated with this threat. Primary measures taken during and after rat confrontation were flight, risk assessment, defensive attack and escape attempts. Unlike the anxiolytic drug diazepam (3-10 microgram/5 microliter, i.c.v.), which affected all defensive responses, OFQ (0.3-3 nM/5 microliter) only clearly reduced defensive upright postures and biting reactions. Subjects displayed these latter defensive behaviors upon forced contact with the threat stimulus, a situation which is considered to be highly stressful. These results suggest that the OFQ system may not be primarily involved in anxiety-related responses including cognitive aspects (i. e., risk assessment), while it may play a role in the adaptative responses to unavoidable or extreme stress stimuli.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8993
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Published by Elsevier Science B.V.
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
836
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Orphanin FQ, a novel neuropeptide with anti-stress-like activity.
pubmed:affiliation
CNS Research Department, Synthélabo Recherche, 31, avenue Paul Vaillant-Couturier, 92220 Bagneux, France. ggriebel@bagneux.synthelabo.fr
pubmed:publicationType
Journal Article