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pubmed-article:10415390pubmed:abstractTextThis study determined baroreceptor reflex (BR) function in conscious rats which had received sham or electrolytic lesions of the anteroventral third ventricle (AV3V) 54-56 days previously. Resting mean arterial pressure (MAP) and heart rate (HR) values of the AV3V-lesion rats were similar to those of sham-lesion rats (P>0.05 for both comparisons). The sensitivity of the BR-mediated tachycardia in AV3V-lesion was greater than in sham-lesion rats (-9. 92+/-1.00 vs. -4.54+/-0.45 bpm/mmHg, P<0.05). The sensitivity of the BR-mediated bradycardia in AV3V-lesion rats was also greater than in rats with sham lesions (-3.56+/-0.38 vs. -2.06+/-0.42 bpm/mmHg, P<0. 05). The AV3V lesions did not affect other BR parameters. These findings demonstrate that chronic lesions of the AV3V region increase the sensitivity of the baroreceptor HR reflex in conscious rats.lld:pubmed
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pubmed-article:10415390pubmed:authorpubmed-author:JohnsonA KAKlld:pubmed
pubmed-article:10415390pubmed:authorpubmed-author:LewisS JSJlld:pubmed
pubmed-article:10415390pubmed:authorpubmed-author:BeltzT GTGlld:pubmed
pubmed-article:10415390pubmed:authorpubmed-author:WhalenE JEJlld:pubmed
pubmed-article:10415390pubmed:copyrightInfoCopyright 1999 Published by Elsevier Science B.V.lld:pubmed
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pubmed-article:10415390pubmed:day24lld:pubmed
pubmed-article:10415390pubmed:volume835lld:pubmed
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pubmed-article:10415390pubmed:pagination330-3lld:pubmed
pubmed-article:10415390pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:10415390pubmed:articleTitleEffects of chronic lesions of the anteroventral third ventricle region on baroreceptor reflex function in conscious rats.lld:pubmed
pubmed-article:10415390pubmed:affiliationDepartment of Pharmacology, University of Iowa, Iowa City, IA, 52242-1109, USA.lld:pubmed
pubmed-article:10415390pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10415390pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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