Linked Life Data

10413669

Source:http://linkedlifedata.com/resource/pubmed/id/10413669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-10-28
pubmed:abstractText
The equal distribution of chromosomes during mitosis and meiosis is dependent on the maintenance of sister chromatid cohesion. In this commentary we review the evidence that, during meiosis, the mechanism underlying the cohesion of chromatids along their arms is different from that responsible for cohesion in the centromere region. We then argue that the chromatids on a mitotic chromosome are also tethered along their arms and in the centromere by different mechanisms, and that the functional action of these two mechanisms can be temporally separated under various conditions. Finally, we demonstrate that in the absence of a centromeric tether, arm cohesion is sufficient to maintain chromatid cohesion during prometaphase of mitosis. This finding provides a straightforward explanation for why mutants in proteins responsible for centromeric cohesion in Drosophila (e.g. ord, mei-s332) disrupt meiosis but not mitosis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9533
pubmed:author
pubmed:issnType
Print
pubmed:volume
112 ( Pt 16)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2607-13
pubmed:dateRevised
2011-9-22
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Chromatid cohesion during mitosis: lessons from meiosis.
pubmed:affiliation
Wadsworth Center, New York State Dept of Health, PO Box 509, Albany, New York 12201-0509, USA. rieder@wadsworth.org
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't