rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1 Suppl
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pubmed:dateCreated |
1999-7-27
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pubmed:abstractText |
Gene therapy has many potential applications in neurosurgery. One application involves bone morphogenetic protein-2 (BMP-2), a low-molecular-weight glycoprotein that induces bone formation in vivo. Numerous studies have demonstrated that the BMP-2 protein can enhance spinal fusion. This study was undertaken to determine whether direct injection of an adenoviral construct containing the BMP-2 gene can be used for spinal fusion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Jan
|
pubmed:issn |
0022-3085
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
90
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-14
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10413134-Adenoviridae,
pubmed-meshheading:10413134-Animals,
pubmed-meshheading:10413134-Bone Morphogenetic Protein 2,
pubmed-meshheading:10413134-Bone Morphogenetic Proteins,
pubmed-meshheading:10413134-Cytomegalovirus,
pubmed-meshheading:10413134-Disease Models, Animal,
pubmed-meshheading:10413134-Gene Therapy,
pubmed-meshheading:10413134-Genetic Vectors,
pubmed-meshheading:10413134-Osteogenesis,
pubmed-meshheading:10413134-Promoter Regions, Genetic,
pubmed-meshheading:10413134-Rats,
pubmed-meshheading:10413134-Rats, Nude,
pubmed-meshheading:10413134-Recombinant Proteins,
pubmed-meshheading:10413134-Spinal Fusion,
pubmed-meshheading:10413134-Spine,
pubmed-meshheading:10413134-Transforming Growth Factor beta
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pubmed:year |
1999
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pubmed:articleTitle |
Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy.
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pubmed:affiliation |
Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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