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rdf:type |
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lifeskim:mentions |
umls-concept:C0009013,
umls-concept:C0019627,
umls-concept:C0023467,
umls-concept:C0039195,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C0205165,
umls-concept:C0280141,
umls-concept:C1332717,
umls-concept:C1378511,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
15
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pubmed:dateCreated |
1999-8-23
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pubmed:abstractText |
Effective immunotherapy for human leukemia based on infusions of T lymphocytes requires the identification of effector T cells that target the leukemic stem cell. The transplantation of human acute myeloid leukemia into nonobese diabetic/severe combined immune deficient (SCID) mice has identified a rare leukemic progenitor termed the SCID leukemia-initiating cell, which is present in low frequency in the leukemic population and is essential for establishing leukemic hematopoiesis. Thus, this transplant model may be ideally suited to identify effector T cells with antileukemic activity. We report that CD8(+) cytotoxic T lymphocyte (CTL) clones specific for minor histocompatibility antigens inhibit the engraftment of human acute myeloid leukemia cells in nonobese diabetic/SCID mice and demonstrate that this inhibition is mediated by direct CTL recognition of SCID leukemia-initiating cells. These results indicate that CD8(+) minor histocompatibility antigen-specific CTL may be mediators of the graft-versus-leukemia effect associated with allogeneic hematopoietic cell transplantation and provide an experimental model to identify and select T cell clones for immunotherapy to prevent or treat relapse after allogeneic hematopoietic cell transplantation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-10090944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-1380540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-188440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-2056279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-2265242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-2297567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-234595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-235092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-2648143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-3310002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-3332173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-34792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-3785225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-386133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-7015133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-7509044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-7539551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-7635982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-7655033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-7667640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-8111046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-8135448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-8460155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-8471780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-8608212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-8630379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-8992968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9045297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9053463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9087382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9212098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9255626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9461441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9490709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9694737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9814651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9883837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10411928-9892612
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8639-44
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10411928-Animals,
pubmed-meshheading:10411928-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10411928-Cell Transplantation,
pubmed-meshheading:10411928-Clone Cells,
pubmed-meshheading:10411928-Coculture Techniques,
pubmed-meshheading:10411928-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:10411928-Flow Cytometry,
pubmed-meshheading:10411928-Graft Rejection,
pubmed-meshheading:10411928-Humans,
pubmed-meshheading:10411928-Immunotherapy,
pubmed-meshheading:10411928-Leukemia, Myeloid,
pubmed-meshheading:10411928-Mice,
pubmed-meshheading:10411928-Mice, Inbred NOD,
pubmed-meshheading:10411928-Mice, SCID,
pubmed-meshheading:10411928-Minor Histocompatibility Antigens,
pubmed-meshheading:10411928-Stem Cells,
pubmed-meshheading:10411928-T-Lymphocytes, Cytotoxic
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pubmed:year |
1999
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pubmed:articleTitle |
CD8(+) minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells.
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pubmed:affiliation |
Programs in Cancer/Blood Research and Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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