Source:http://linkedlifedata.com/resource/pubmed/id/10410329
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-10-18
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pubmed:abstractText |
This paper describes the involvement of sex hormones in the edematogenic response produced by staphylococcal enterotoxin B (SEB) in the mouse hindpaw. Both the paw weight variation and the protein exudate produced by the intraplantar administration of SEB (12.5 micrograms/paw) to intact, randomly cycling female (IRCF) mice were significantly attenuated when the animals were ovariectomized (OVX). The attenuation of SEB-induced paw swelling produced by OVX was not reversed by estradiol (OE2) reposition. Thus, 4 h after the injection of SEB the increase in paw weight in OVX-mice treated with OE2 (10 micrograms/kg in corn oil) was 15.0 +/- 0.9 mg, while the exudation corresponded to 2.1 +/- 0.3 micrograms of Evans blue dye/g of tissue. Neither of these values differed significantly from those obtained 4 h after the intraplantar injection of SEB (12.5 micrograms/paw) in non-treated OVX-mice (paw swelling, 14.0 +/- 0.8 mg; dye exudation, 2.0 +/- 0.3 micrograms/g, N = 6). Pretreating IRCF mice once a day for three days with human chorionic gonadotrophin (40 IU/kg, i.m.) reduced the paw edema produced by the toxin, thus indicating an involvement of gonadotrophins in this event. A pronounced decrease in paw weight variation (about 45%) and dye exudation (61%) was detected when IRCF mice were previously treated every 72 h with three injections of OE2 (10 micrograms/kg in corn oil, i.m.). Similar situations were also seen when the animals were pretreated at 72 h intervals with three injections of testosterone (10 mg/kg in corn oil, i.m.). We conclude that the paw edema induced by SEB in female mice is hormonally regulated. Our results also indicate that the HPA-immune axis is involved in this phenomenon.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Evans Blue,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropins,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin B, staphylococcal
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1058-8108
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-88
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10410329-Animals,
pubmed-meshheading:10410329-Dose-Response Relationship, Drug,
pubmed-meshheading:10410329-Edema,
pubmed-meshheading:10410329-Enterotoxins,
pubmed-meshheading:10410329-Escherichia coli,
pubmed-meshheading:10410329-Estradiol,
pubmed-meshheading:10410329-Evans Blue,
pubmed-meshheading:10410329-Female,
pubmed-meshheading:10410329-Gonadotropins,
pubmed-meshheading:10410329-Hindlimb,
pubmed-meshheading:10410329-Humans,
pubmed-meshheading:10410329-Mice,
pubmed-meshheading:10410329-Ovariectomy,
pubmed-meshheading:10410329-Random Allocation,
pubmed-meshheading:10410329-Testosterone
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pubmed:year |
1999
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pubmed:articleTitle |
The hind paw edema produced by staphylococcal enterotoxin B in female mice is modulated by sex hormones.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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