|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1999-9-8
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The Dhm1 gene is the mouse homologue of the dhp1(+) gene of Schizosaccharomyces pombe, which is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking, in S. pombe. Complementation analysis showed the Dhm1 gene on a multicopy plasmid can rescue the temperature-sensitivity mutation of dhp1(ts) and the lethality of the dhp1 null mutation. This finding suggests that Dhm1 has a function in mouse similar to that of dhp1(+). The human homologue of this gene, XRN2, has been identified. A 3.6-kb transcript of XRN2 was detected in 16 tissues examined and was more abundant in testis. By radiation hybrid panel mapping, the XRN2 gene was localized to chromosome 20p11.1-p11.2 between markers D20S180 and D20S871.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0888-7543
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 1999 Academic Press.
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
59
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
252-4
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10409438-Adult,
pubmed-meshheading:10409438-Amino Acid Sequence,
pubmed-meshheading:10409438-Blotting, Northern,
pubmed-meshheading:10409438-Chromosome Banding,
pubmed-meshheading:10409438-Chromosome Mapping,
pubmed-meshheading:10409438-Chromosomes, Human, Pair 20,
pubmed-meshheading:10409438-Cloning, Molecular,
pubmed-meshheading:10409438-DNA, Complementary,
pubmed-meshheading:10409438-Exoribonucleases,
pubmed-meshheading:10409438-Female,
pubmed-meshheading:10409438-Gene Expression,
pubmed-meshheading:10409438-Genes,
pubmed-meshheading:10409438-Humans,
pubmed-meshheading:10409438-Male,
pubmed-meshheading:10409438-Molecular Sequence Data,
pubmed-meshheading:10409438-Proteins,
pubmed-meshheading:10409438-RNA, Messenger,
pubmed-meshheading:10409438-Sequence Alignment,
pubmed-meshheading:10409438-Sequence Analysis, DNA,
pubmed-meshheading:10409438-Sequence Homology, Amino Acid,
pubmed-meshheading:10409438-Tissue Distribution
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2.
|
|
pubmed:affiliation |
The Institute of Genetics, Fudan University, Shanghai, 200433, People's Republic of China.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
