| pubmed-article:10409212 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10409212 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:10409212 | lifeskim:mentions | umls-concept:C1564871 | lld:lifeskim |
| pubmed-article:10409212 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10409212 | lifeskim:mentions | umls-concept:C1420229 | lld:lifeskim |
| pubmed-article:10409212 | lifeskim:mentions | umls-concept:C1621574 | lld:lifeskim |
| pubmed-article:10409212 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:10409212 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:10409212 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10409212 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10409212 | pubmed:issue | 1 Pt 2 | lld:pubmed |
| pubmed-article:10409212 | pubmed:dateCreated | 1999-8-30 | lld:pubmed |
| pubmed-article:10409212 | pubmed:abstractText | The cardiac sarcolemmal Na(+)/Ca(2+) exchanger plays a primary role in Ca(2+) efflux and is important in regulating intracellular Ca(2+) and beat-to-beat contractility. Of the three Na(+)/Ca(2+) exchanger genes cloned (NCX1, NCX2, and NCX3), only NCX1 is expressed in cardiac myocytes. NCX1 has alternative promoters for heart, kidney, and brain tissue-specific transcripts. Analysis of the cardiac NCX1 promoter (at -336 bp) identified a cardiac-specific minimum promoter (at -137) and two GATA sites (at -75 and -145). In this study, gel shift and supershift analyses identified GATA-4 in primary neonatal cardiac myocytes. Site-directed mutagenesis of the GATA-4 site at -75 abolishes binding and reduces activity of the minimum and full-length promoters by >90 and approximately 60%, respectively. Mutation of the GATA site at -145 reduces activity of the full-length promoter by approximately 30%. Mutation of an E-box at -175 does not alter promoter activity. | lld:pubmed |
| pubmed-article:10409212 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10409212 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10409212 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10409212 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10409212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10409212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10409212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10409212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10409212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10409212 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10409212 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10409212 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:10409212 | pubmed:author | pubmed-author:PhilipsonK... | lld:pubmed |
| pubmed-article:10409212 | pubmed:author | pubmed-author:NicholasS BSB | lld:pubmed |
| pubmed-article:10409212 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10409212 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:10409212 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10409212 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10409212 | pubmed:pagination | H324-30 | lld:pubmed |
| pubmed-article:10409212 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10409212 | pubmed:meshHeading | pubmed-meshheading:10409212... | lld:pubmed |
| pubmed-article:10409212 | pubmed:meshHeading | pubmed-meshheading:10409212... | lld:pubmed |
| pubmed-article:10409212 | pubmed:meshHeading | pubmed-meshheading:10409212... | lld:pubmed |
| pubmed-article:10409212 | pubmed:meshHeading | pubmed-meshheading:10409212... | lld:pubmed |
| pubmed-article:10409212 | pubmed:meshHeading | pubmed-meshheading:10409212... | lld:pubmed |
| pubmed-article:10409212 | pubmed:meshHeading | pubmed-meshheading:10409212... | lld:pubmed |
| pubmed-article:10409212 | pubmed:meshHeading | pubmed-meshheading:10409212... | lld:pubmed |
| pubmed-article:10409212 | pubmed:meshHeading | pubmed-meshheading:10409212... | lld:pubmed |
| pubmed-article:10409212 | pubmed:meshHeading | pubmed-meshheading:10409212... | lld:pubmed |
| pubmed-article:10409212 | pubmed:meshHeading | pubmed-meshheading:10409212... | lld:pubmed |
| pubmed-article:10409212 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10409212 | pubmed:articleTitle | Cardiac expression of the Na(+)/Ca(2+) exchanger NCX1 is GATA factor dependent. | lld:pubmed |
| pubmed-article:10409212 | pubmed:affiliation | Departments of Physiology and Medicine and the Cardiovascular Research Laboratories, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095-1760, USA. snichola@med1.medsch.ucla.edu | lld:pubmed |
| pubmed-article:10409212 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10409212 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10409212 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10409212 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10409212 | lld:pubmed |
