Linked Life Data

10408914

Source:http://linkedlifedata.com/resource/pubmed/id/10408914

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-7-15
pubmed:abstractText
Alpha-tocopherol at low concentrations protects biosubstrates from oxidative damage, while at high concentrations it may become toxic. Certain lines of tumor cells are reported to contain higher levels of vitamin E than normal cells. In our study alpha-tocopherol was successfully incorporated by cultured HT29 adenocarcinoma cells, but not by MRC-5 normal fibroblasts. At high concentrations (0.3-1 mM) alpha-tocopherol enhanced meta-tetra(hydroxyphenyl)chlorin (mTHPC)-sensitized photoinactivation of HT29 cells (415 nm), but not that of normal fibroblasts. At none of the concentrations used (0.001-1 mM) did alpha-tocopherol protect cells from photokilling, indicating that lipid peroxidation is of minor importance in mTHPC photoactivity. Our findings encourage the in vivo testing of phenolic antioxidants for selective enhancement of PDT-damage in tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
139
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Meta-tetra(hydroxyphenyl)chlorin-sensitized photodynamic damage of cultured tumor and normal cells in the presence of high concentrations of alpha-tocopherol.
pubmed:affiliation
Unité de Recherche en Thérapie Photodynamique, Centre Alexis Vautrin, Vandoeuvre-les-Nancy, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't