Linked Life Data

10407129

Source:http://linkedlifedata.com/resource/pubmed/id/10407129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-9-13
pubmed:abstractText
The laminar location of a neuron in the mature cortex is defined by early events in its ontogeny. In the present study, quantitative [(3)H]thymidine ([(3)H]dT) autoradiography was used to define some of these early events. Four indices were calculated: a proliferation index (indicative of the fraction of cells that was cycling), the leaving fraction (the fraction of cells that permanently left the cycling population and migrated to cortex, the release time (the time post-mitotic cells remained in the proliferative zone(s) before initiating their migrations), and the rate of migration. The proliferation index was relatively high on G13 and progressively declined to a nadir on G21. In contrast, the leaving fraction was lowest on G13 and on G21. The release time for a particular subpopulation did not vary with the time of origin. On the other hand, the release time for the earliest generated cells was significantly shorter than it was for the remaining population of cells labeled by a particular injection of [(3)H]dT. The mean rate of migration was affected by neither the time of origin nor the timing of the onset of migration. Thus, once a cell becomes permanently post-mitotic, the behavior of the young neuron (as defined by its release time and rate of migration) is highly ordered. It is the time of origin, as determined by the desynchrony of the cycling activity of proliferating cells, that determines the ultimate disposition of a cortical neuron.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0165-3806
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Elsevier Science B.V.
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-22
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Kinetics of the migration of neurons to rat somatosensory cortex.
pubmed:affiliation
Research Service, Veterans Affairs Medical Center, Iowa City, IA 52246, USA. mwmiller@blue.weeg.uiowa.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.