Linked Life Data

10407114

Source:http://linkedlifedata.com/resource/pubmed/id/10407114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1999-9-10
pubmed:abstractText
In an attempt to elucidate whether glial cell line-derived neurotrophic factor (GDNF) receptors are induced after ischemic brain injury, possible expression of immunoreactive GDNF receptor-alpha1 (GFRalpha-1) and c-ret (RET) was examined at 3, 8, or 24 h after permanent middle cerebral artery occlusion (MCAO) in rats. Immunohistochemical study showed that both GFRalpha-1 and RET staining cells which were not detected in sham control brain, were present in the ipsilateral cortex and caudate at 3 to 8 h after permanent MCAO, and then decreased but remained to some extent at 24 h. Positive cells for both GDNF receptors were predominantly in cortical neurons of ischemic penumbral area. Western blot analysis confirmed the induction of those receptors after permanent MCAO. This rapid induction of GFRalpha-1 and RET, which correlates with the similar induction of GDNF under these conditions, may play a role in the early response to ischemic brain injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8993
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Elsevier Science B.V.
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
834
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
190-5
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10407114-Animals, pubmed-meshheading:10407114-Arterial Occlusive Diseases, pubmed-meshheading:10407114-Blotting, Western, pubmed-meshheading:10407114-Cerebral Arteries, pubmed-meshheading:10407114-Cerebral Cortex, pubmed-meshheading:10407114-Corpus Striatum, pubmed-meshheading:10407114-Drosophila Proteins, pubmed-meshheading:10407114-Glial Cell Line-Derived Neurotrophic Factor Receptors, pubmed-meshheading:10407114-Immunohistochemistry, pubmed-meshheading:10407114-Male, pubmed-meshheading:10407114-Proto-Oncogene Proteins, pubmed-meshheading:10407114-Proto-Oncogene Proteins c-ret, pubmed-meshheading:10407114-Rats, pubmed-meshheading:10407114-Rats, Wistar, pubmed-meshheading:10407114-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:10407114-Staining and Labeling, pubmed-meshheading:10407114-Time Factors
pubmed:year
1999
pubmed:articleTitle
Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats.
pubmed:affiliation
Department of Neurology, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700-8558, Japan. q_kitagawa@research.otsuka.co.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't