Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1999-8-2
pubmed:abstractText
In an attempt to characterize the contribution of the 5-HT1B receptor to behavior, 5-HT1B knock-out (KO) mice were subjected to a battery of behavioral paradigms aimed at differentiating various components of cognitive and emotional behaviors. In an object exploration task, wild-type (WT) and 5-HT1B KO mice did not differ in locomotor activity. 5-HT1B KO mice, however, displayed lower thigmotaxis (an index of anxiety) associated with a higher level of object exploratory activity, but no genotype differences were observed in the elevated plus maze. 5-HT1B KO mice also displayed a lack of exploratory habituation. In the spatial version of the Morris water maze, 5-HT1B KO mice showed higher performances in acquisition and transfer test, which was not observed in the visual version of the task. No genotype differences were found in contextual fear conditioning, because both WT and 5-HT1B KO mice were able to remember the context where they had received the aversive stimulus. The deletion of the 5-HT1B receptor, associated with appropriate behavioral paradigms, thus allowed us to dissociate anxiety from response to novelty, and perseverative behavior (lack of habituation) from adaptive behavioral inhibition underlying cognitive flexibility (transfer stage in the water maze). The deletion of the 5-HT1B receptor did not result in significant developmental plasticities for other major 5-HT receptor types but may have influenced other neurotransmission systems. The 5-HT1B receptor may be a key target for serotonin in the modulation of cognitive behavior, particularly in situations involving a high cognitive demand.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6157-68
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10407051-Analysis of Variance, pubmed-meshheading:10407051-Animals, pubmed-meshheading:10407051-Anxiety, pubmed-meshheading:10407051-Avoidance Learning, pubmed-meshheading:10407051-Conditioning, Operant, pubmed-meshheading:10407051-Electroshock, pubmed-meshheading:10407051-Exploratory Behavior, pubmed-meshheading:10407051-Fear, pubmed-meshheading:10407051-Homozygote, pubmed-meshheading:10407051-Male, pubmed-meshheading:10407051-Maze Learning, pubmed-meshheading:10407051-Memory, pubmed-meshheading:10407051-Mice, pubmed-meshheading:10407051-Mice, Inbred Strains, pubmed-meshheading:10407051-Mice, Knockout, pubmed-meshheading:10407051-Motor Activity, pubmed-meshheading:10407051-Receptor, Serotonin, 5-HT1B, pubmed-meshheading:10407051-Receptors, Serotonin, pubmed-meshheading:10407051-Space Perception
pubmed:year
1999
pubmed:articleTitle
5-HT1B receptor knock-out mice exhibit increased exploratory activity and enhanced spatial memory performance in the Morris water maze.
pubmed:affiliation
Laboratoire de Neurosciences Comportementales et Cognitives, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5807, Université de Bordeaux 1, 33405 Talence cedex, France.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't