Source:http://linkedlifedata.com/resource/pubmed/id/10406653
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
13
|
| pubmed:dateCreated |
1999-10-14
|
| pubmed:abstractText |
A series of beta-diketone acrylate bioisosteres 4 of pseudomonic acid A 1 have been synthesized and evaluated for their ability to inhibit bacterial isoleucyl-tRNA synthetase and act as antibacterial agents. A number of analogues have excellent antibacterial activity. Selected examples were shown to afford good blood levels and to be effective in a murine infection model.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
5
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1847-52
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10406653-Animals,
pubmed-meshheading:10406653-Anti-Bacterial Agents,
pubmed-meshheading:10406653-Ketones,
pubmed-meshheading:10406653-Kinetics,
pubmed-meshheading:10406653-Male,
pubmed-meshheading:10406653-Mice,
pubmed-meshheading:10406653-Mupirocin,
pubmed-meshheading:10406653-Staphylococcus aureus
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Synthesis and antibacterial properties of beta-diketone acrylate bioisosteres of pseudomonic acid A.
|
| pubmed:affiliation |
SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Harlow, Essex, UK.
|
| pubmed:publicationType |
Journal Article
|