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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-9-24
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pubmed:abstractText |
Although the activity of the liver in metabolizing and eliminating various drugs decreases in endotoxemia, the mechanism remains to be elucidated. The generation of nitric oxide by the inducible type of nitric oxide synthase increases in endotoxemia. Nitric oxide readily reacts with heme proteins such as cytochrome P450 that metabolize various compounds, including steroids and eicosanoids. The purpose of this study was to determine the effect of nitric oxide on the function of hepatic cytochrome P450 in endotoxemic rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Hypnotics and Sedatives,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Midazolam,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrites,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Steroid Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/steroid hormone 6-beta-hydroxylase
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1035-44
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10406181-Animals,
pubmed-meshheading:10406181-Cytochrome P-450 Enzyme System,
pubmed-meshheading:10406181-Endotoxemia,
pubmed-meshheading:10406181-Hydroxylation,
pubmed-meshheading:10406181-Hypnotics and Sedatives,
pubmed-meshheading:10406181-Lipopolysaccharides,
pubmed-meshheading:10406181-Male,
pubmed-meshheading:10406181-Microsomes, Liver,
pubmed-meshheading:10406181-Midazolam,
pubmed-meshheading:10406181-Nitrates,
pubmed-meshheading:10406181-Nitric Oxide,
pubmed-meshheading:10406181-Nitric Oxide Synthase,
pubmed-meshheading:10406181-Nitric Oxide Synthase Type II,
pubmed-meshheading:10406181-Nitrites,
pubmed-meshheading:10406181-Rats,
pubmed-meshheading:10406181-Rats, Wistar,
pubmed-meshheading:10406181-Steroid Hydroxylases,
pubmed-meshheading:10406181-Testosterone
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pubmed:year |
1999
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pubmed:articleTitle |
Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia.
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pubmed:affiliation |
Department of Surgery, Osaka City University Medical School, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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