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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-8-31
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pubmed:databankReference |
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pubmed:abstractText |
Bleomycin hydrolase (BH) is a cysteine protease that is found in all tissues in mammals as well as in many other eukaryotes and prokaryotes. Although its conserved cellular function is as yet unknown, human bleomycin hydrolase (hBH) has clinical significance in that it is thought to be the major cause of tumor cell resistance to bleomycin chemotherapy. In addition, it has been reported that an allelic variant of hBH is genetically linked to Alzheimer's disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
619-27
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10404591-Alzheimer Disease,
pubmed-meshheading:10404591-Amino Acid Sequence,
pubmed-meshheading:10404591-Antineoplastic Agents,
pubmed-meshheading:10404591-Binding Sites,
pubmed-meshheading:10404591-Bleomycin,
pubmed-meshheading:10404591-Crystallography, X-Ray,
pubmed-meshheading:10404591-Cysteine Endopeptidases,
pubmed-meshheading:10404591-DNA-Binding Proteins,
pubmed-meshheading:10404591-Drug Resistance,
pubmed-meshheading:10404591-Fluorescent Antibody Technique,
pubmed-meshheading:10404591-Fungal Proteins,
pubmed-meshheading:10404591-Humans,
pubmed-meshheading:10404591-Hydrogen Bonding,
pubmed-meshheading:10404591-Models, Molecular,
pubmed-meshheading:10404591-Molecular Sequence Data,
pubmed-meshheading:10404591-Mutation,
pubmed-meshheading:10404591-Protein Conformation,
pubmed-meshheading:10404591-Recombinant Proteins,
pubmed-meshheading:10404591-Static Electricity
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pubmed:year |
1999
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pubmed:articleTitle |
Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.
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pubmed:affiliation |
WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, NY 11724, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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