| pubmed-article:10402461 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10402461 | lifeskim:mentions | umls-concept:C0120465 | lld:lifeskim |
| pubmed-article:10402461 | lifeskim:mentions | umls-concept:C1412510 | lld:lifeskim |
| pubmed-article:10402461 | lifeskim:mentions | umls-concept:C1415002 | lld:lifeskim |
| pubmed-article:10402461 | lifeskim:mentions | umls-concept:C0870432 | lld:lifeskim |
| pubmed-article:10402461 | lifeskim:mentions | umls-concept:C1705417 | lld:lifeskim |
| pubmed-article:10402461 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:10402461 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10402461 | lifeskim:mentions | umls-concept:C1555465 | lld:lifeskim |
| pubmed-article:10402461 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10402461 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10402461 | pubmed:dateCreated | 1999-8-9 | lld:pubmed |
| pubmed-article:10402461 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10402461 | pubmed:abstractText | Expression cloning from a cDNA library prepared from a mutant CHO cell line with Golgi-specific resistance to Brefeldin A (BFA) identified a novel 206-kD protein with a Sec7 domain termed GBF1 for Golgi BFA resistance factor 1. Overexpression of GBF1 allowed transfected cells to maintain normal Golgi morphology and grow in the presence of BFA. Golgi- enriched membrane fractions from such transfected cells displayed normal levels of ADP ribosylation factors (ARFs) activation and coat protein recruitment that were, however, BFA resistant. Hexahistidine-tagged-GBF1 exhibited BFA-resistant guanine nucleotide exchange activity that appears specific towards ARF5 at physiological Mg2+concentration. Characterization of cDNAs recovered from the mutant and wild-type parental lines established that transcripts in these cells had identical sequence and, therefore, that GBF1 was naturally BFA resistant. GBF1 was primarily cytosolic but a significant pool colocalized to a perinuclear structure with the beta-subunit of COPI. Immunogold labeling showed highest density of GBF1 over Golgi cisternae and significant labeling over pleiomorphic smooth vesiculotubular structures. The BFA-resistant nature of GBF1 suggests involvement in retrograde traffic. | lld:pubmed |
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| pubmed-article:10402461 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10402461 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10402461 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10402461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10402461 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10402461 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10402461 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:10402461 | pubmed:author | pubmed-author:BergerS JSJ | lld:pubmed |
| pubmed-article:10402461 | pubmed:author | pubmed-author:ShiE CEC | lld:pubmed |
| pubmed-article:10402461 | pubmed:author | pubmed-author:DahanSS | lld:pubmed |
| pubmed-article:10402461 | pubmed:author | pubmed-author:ClaudeAA | lld:pubmed |
| pubmed-article:10402461 | pubmed:author | pubmed-author:MelançonPP | lld:pubmed |
| pubmed-article:10402461 | pubmed:author | pubmed-author:SullivanE MEM | lld:pubmed |
| pubmed-article:10402461 | pubmed:author | pubmed-author:ZhaoB PBP | lld:pubmed |
| pubmed-article:10402461 | pubmed:author | pubmed-author:KuziemskyC... | lld:pubmed |
| pubmed-article:10402461 | pubmed:author | pubmed-author:ArmoldA DAD | lld:pubmed |
| pubmed-article:10402461 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10402461 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:10402461 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:10402461 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10402461 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10402461 | pubmed:pagination | 71-84 | lld:pubmed |
| pubmed-article:10402461 | pubmed:dateRevised | 2010-10-8 | lld:pubmed |
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| pubmed-article:10402461 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10402461 | pubmed:articleTitle | GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5. | lld:pubmed |
| pubmed-article:10402461 | pubmed:affiliation | Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7. | lld:pubmed |
