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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-9-8
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pubmed:abstractText |
TSH-independent mutant clones (M cells) derived from FRTL5 cells, proliferate vigorously in the absence of TSH. The growth of M cells is stimulated by IGF-I in a dose-dependent fashion, but it is not influenced by TSH. Sm1.2, an antibody against IGF-I cross-reacting with IGF-II, significantly decreases basal DNA synthesis in the M cells. Binding of 125I-IGF-I to M cells is significantly lower than that to FRTL5 cells. M cells produce in their culture medium IGF-like peptides which appear to influence their basal DNA synthesis and the availability of type I receptors to bind exogenous IGF-I.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0300-9084
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
367-71
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10401671-Animals,
pubmed-meshheading:10401671-Cattle,
pubmed-meshheading:10401671-Cell Division,
pubmed-meshheading:10401671-Cell Line,
pubmed-meshheading:10401671-DNA,
pubmed-meshheading:10401671-Insulin-Like Growth Factor I,
pubmed-meshheading:10401671-Insulin-Like Growth Factor II,
pubmed-meshheading:10401671-Mitogens,
pubmed-meshheading:10401671-Mutation,
pubmed-meshheading:10401671-Rats,
pubmed-meshheading:10401671-Receptor, IGF Type 1,
pubmed-meshheading:10401671-Thyroid Gland,
pubmed-meshheading:10401671-Thyrotropin
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pubmed:year |
1999
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pubmed:articleTitle |
Endogenous insulin-like growth factors regulate the proliferation of TSH-independent mutants derived from FRTL5 cells.
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pubmed:affiliation |
CEOS/CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare Luigi Califano, Università di Napoli Federico II Naples, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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