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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1999-8-24
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pubmed:abstractText |
Cellular immune responses are thought to be an important antiviral host defense, but the relationship between virus-specific T-helper and cytotoxic-T-lymphocyte (CTL) responses has not been defined. To investigate a potential link between these responses, we examined functional human immunodeficiency virus type 1 (HIV-1)-specific memory CTL precursor frequencies and p24-specific proliferative responses in a cohort of infected untreated persons with a wide range of viral loads and CD4 cell counts. Levels of p24-specific proliferative responses positively correlated with levels of Gag-specific CTL precursors and negatively correlated with levels of plasma HIV-1 RNA. These data linking the levels of HIV-specific CTL with virus-specific helper cell function during chronic viral infection provide cellular immunologic parameters to guide therapeutic and prophylactic vaccine development.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-1652311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-1673465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-1744586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-7040548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-7523570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-7585062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-7622874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-7637030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-7699324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-7966595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-8043040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-8057491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-8093890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-8145043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-8207839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-8551565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-8743084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-8786327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-9060635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-9060675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-9126923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-9367954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-9516110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-9616227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-9806028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-9847391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-9858506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10400769-9858507
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6715-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10400769-Cell Division,
pubmed-meshheading:10400769-Chronic Disease,
pubmed-meshheading:10400769-Cohort Studies,
pubmed-meshheading:10400769-Gene Products, gag,
pubmed-meshheading:10400769-HIV Core Protein p24,
pubmed-meshheading:10400769-HIV Infections,
pubmed-meshheading:10400769-HIV-1,
pubmed-meshheading:10400769-Humans,
pubmed-meshheading:10400769-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:10400769-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:10400769-Viremia
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pubmed:year |
1999
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pubmed:articleTitle |
Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection.
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pubmed:affiliation |
Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA. kalams@helix.mgh.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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