Source:http://linkedlifedata.com/resource/pubmed/id/10399936
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-10-28
|
| pubmed:abstractText |
Reactive astrocytes adjacent to a forebrain stab injury were selectively ablated in adult mice expressing HSV-TK from the Gfap promoter by treatment with ganciclovir. Injured tissue that was depleted of GFAP-positive astrocytes exhibited (1) a prolonged 25-fold increase in infiltration of CD45-positive leukocytes, including ultrastructurally identified monocytes, macrophages, neutrophils, and lymphocytes, (2) failure of blood-brain barrier (BBB) repair, (3) substantial neuronal degeneration that could be attenuated by chronic glutamate receptor blockade, and (4) a pronounced increase in local neurite outgrowth. These findings show that genetic targeting can be used to ablate scar-forming astrocytes and demonstrate roles for astrocytes in regulating leukocyte trafficking, repairing the BBB, protecting neurons, and restricting nerve fiber growth after injury in the adult central nervous system.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0896-6273
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
297-308
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| pubmed:dateRevised |
2009-9-29
|
| pubmed:meshHeading |
pubmed-meshheading:10399936-Animals,
pubmed-meshheading:10399936-Astrocytes,
pubmed-meshheading:10399936-Blood-Brain Barrier,
pubmed-meshheading:10399936-Brain Injuries,
pubmed-meshheading:10399936-Cell Count,
pubmed-meshheading:10399936-Cell Movement,
pubmed-meshheading:10399936-Female,
pubmed-meshheading:10399936-Ganciclovir,
pubmed-meshheading:10399936-Gene Expression Regulation,
pubmed-meshheading:10399936-Glial Fibrillary Acidic Protein,
pubmed-meshheading:10399936-Hippocampus,
pubmed-meshheading:10399936-Histocytochemistry,
pubmed-meshheading:10399936-Leukocytes,
pubmed-meshheading:10399936-Mice,
pubmed-meshheading:10399936-Mice, Transgenic,
pubmed-meshheading:10399936-Nerve Degeneration,
pubmed-meshheading:10399936-Neurites,
pubmed-meshheading:10399936-Neurons,
pubmed-meshheading:10399936-Simplexvirus,
pubmed-meshheading:10399936-Thymidine Kinase,
pubmed-meshheading:10399936-Wounds, Stab
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice.
|
| pubmed:affiliation |
Medical Research Council Cambridge Centre for Brain Repair, and Department of Anatomy, University of Cambridge, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|