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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1999-7-29
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pubmed:databankReference |
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pubmed:abstractText |
S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci by a range of environmental cues. We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related members of the S100/calgranulin superfamily. Interaction of EN-RAGEs with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Blockade of EN-RAGE/RAGE quenches delayed-type hypersensitivity and inflammatory colitis in murine models by arresting activation of central signaling pathways and expression of inflammatory gene mediators. These data highlight a novel paradigm in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular activation and tissue injury.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:AvilaCC,
pubmed-author:BeachDD,
pubmed-author:BierhausAA,
pubmed-author:DrurySS,
pubmed-author:FuCC,
pubmed-author:HofmannM AMA,
pubmed-author:KambhamNN,
pubmed-author:LoSS,
pubmed-author:McClaryJJ,
pubmed-author:MorserJJ,
pubmed-author:NagashimaMM,
pubmed-author:NawrothPP,
pubmed-author:NeurathM FMF,
pubmed-author:RiDD,
pubmed-author:SchmidtA MAM,
pubmed-author:SlatteryTT,
pubmed-author:SterzHH,
pubmed-author:TaguchiAA
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
889-901
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10399917-Amino Acid Sequence,
pubmed-meshheading:10399917-Animals,
pubmed-meshheading:10399917-Base Sequence,
pubmed-meshheading:10399917-Cattle,
pubmed-meshheading:10399917-Colitis,
pubmed-meshheading:10399917-DNA, Complementary,
pubmed-meshheading:10399917-Endothelium, Vascular,
pubmed-meshheading:10399917-Female,
pubmed-meshheading:10399917-Humans,
pubmed-meshheading:10399917-Jurkat Cells,
pubmed-meshheading:10399917-Leukocytes, Mononuclear,
pubmed-meshheading:10399917-Membrane Proteins,
pubmed-meshheading:10399917-Mice,
pubmed-meshheading:10399917-Mice, Inbred C57BL,
pubmed-meshheading:10399917-Molecular Sequence Data,
pubmed-meshheading:10399917-Peptides,
pubmed-meshheading:10399917-Phagocytes,
pubmed-meshheading:10399917-Receptors, Immunologic,
pubmed-meshheading:10399917-S100 Proteins
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pubmed:year |
1999
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pubmed:articleTitle |
RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides.
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pubmed:affiliation |
College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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