Source:http://linkedlifedata.com/resource/pubmed/id/10397713
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-8-5
|
| pubmed:abstractText |
Peripheral blood stem cell (PBSC) transplants from HLA-A, -B, and -DR compatible unrelated donors (n = 45) were compared with bone marrow (BM; BM group, n = 45). Eighteen patients received CD34-selected PBSC (CD34 group). The PBSCs contained more mononuclear cells, CD34(+), CD3(+), and CD56(+) cells compared with marrow (P <.001). Engraftment was achieved in all 45 patients in the BM group, in 43 of 45 (95%) in the PBSC group, and in 14 of 18 (78%) in the CD34 group (P <.01). In multivariate analysis, a short time to absolute neutrophil count (ANC) equal to 0.5 x 10(9)/L was associated with the PBSC/CD34 groups (P <.001) and granulocyte colony-stimulating factor (G-CSF) treatment (P =.017). A short time to platelets equal to 50 x 10(9)/L was associated with PBSC (P =. 003) and no methotrexate (P =.015). Grades II-IV acute graft-versus-host disease (GVHD) was 20% in the BM controls, 30% in the PBSC group, and 18% in the CD34 group (not significant [NS]). The probability of chronic GVHD was 85% in the BM group, 59% in the PBSC group, and 0% in the CD34 group (P <.01). One-year transplant-related mortality was 21% and 27% and survival was 53% and 54% in the BM and PBSC groups, respectively (NS). The 2-year relapse-free survival was 41% and 46% in the two groups, respectively.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0006-4971
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| pubmed:author |
pubmed-author:BasaraNN,
pubmed-author:BataBB,
pubmed-author:BeelenD WDW,
pubmed-author:BlauI WIW,
pubmed-author:BornhäuserMM,
pubmed-author:EhningerGG,
pubmed-author:FauserA AAA,
pubmed-author:HägglundHH,
pubmed-author:HöligKK,
pubmed-author:RembergerMM,
pubmed-author:RingdénOO,
pubmed-author:RundeVV
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
94
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
455-64
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10397713-Adult,
pubmed-meshheading:10397713-Bone Marrow Transplantation,
pubmed-meshheading:10397713-Cause of Death,
pubmed-meshheading:10397713-Disease-Free Survival,
pubmed-meshheading:10397713-Female,
pubmed-meshheading:10397713-Graft Survival,
pubmed-meshheading:10397713-Graft vs Host Disease,
pubmed-meshheading:10397713-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:10397713-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:10397713-Humans,
pubmed-meshheading:10397713-Incidence,
pubmed-meshheading:10397713-Leukocyte Count,
pubmed-meshheading:10397713-Male,
pubmed-meshheading:10397713-Methotrexate,
pubmed-meshheading:10397713-Middle Aged,
pubmed-meshheading:10397713-Neutrophils,
pubmed-meshheading:10397713-Prospective Studies,
pubmed-meshheading:10397713-Recurrence,
pubmed-meshheading:10397713-Survival Analysis,
pubmed-meshheading:10397713-Tissue Donors,
pubmed-meshheading:10397713-Transplantation, Homologous,
pubmed-meshheading:10397713-Transplantation Conditioning,
pubmed-meshheading:10397713-Treatment Outcome
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Peripheral blood stem cell transplantation from unrelated donors: a comparison with marrow transplantation.
|
| pubmed:affiliation |
Center for Allogeneic Stem Cell Transplantation, Department of Clinical Immunology, Huddinge Hospital, Huddinge, Sweden. olle.ringden@immunlab.hs.sll.se
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't,
Multicenter Study
|