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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1999-7-16
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pubmed:abstractText |
This study was designed to determine whether changes in p27Kip1 expression are involved in human hepatocarcinogenesis. We examined the p27Kip1 mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27Kip1 mRNA expression levels (ratio of p27Kip1/beta-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49 +/- 0.24 versus 0.57 +/- 0.22, P < 0.05). p27Kip1 mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27Kip1 expression may be at least partly responsible for human hepatocarcinogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0304-3835
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
132
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
67-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10397455-Adult,
pubmed-meshheading:10397455-Aged,
pubmed-meshheading:10397455-Carcinoma, Hepatocellular,
pubmed-meshheading:10397455-Cell Cycle Proteins,
pubmed-meshheading:10397455-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:10397455-Female,
pubmed-meshheading:10397455-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10397455-Humans,
pubmed-meshheading:10397455-Immunohistochemistry,
pubmed-meshheading:10397455-Liver,
pubmed-meshheading:10397455-Liver Neoplasms,
pubmed-meshheading:10397455-Male,
pubmed-meshheading:10397455-Microtubule-Associated Proteins,
pubmed-meshheading:10397455-Middle Aged,
pubmed-meshheading:10397455-RNA, Messenger,
pubmed-meshheading:10397455-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10397455-Tumor Suppressor Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Reduced p27Kip1 expression in hepatocellular carcinomas.
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pubmed:affiliation |
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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