10397451

Source:http://linkedlifedata.com/resource/pubmed/id/10397451

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0008838, umls-concept:C0017262, umls-concept:C0185117, umls-concept:C0442027, umls-concept:C0596402, umls-concept:C1533691, umls-concept:C2347610, umls-concept:C2349952, umls-concept:C2911684
pubmed:issue	1-2
pubmed:dateCreated	1999-7-16
pubmed:abstractText	We investigated the expression of hMSH2, a human mutS homologue from chromosome 2p, in oral and oropharyngeal squamous cell carcinoma (SCC) by an immunohistochemical technique and performed tumor in vitro chemosensitivity testing. In 58 oral and oropharyngeal SCC, the hMSH2 positive score was inversely associated with tumor size, but not with other clinical parameters. Among five anticancer drugs (cisplatin (CDDP), 5-FU, peplomycin, mitomycin C and doxorubicin), only for CDDP was sensitivity to cytotoxicity correlated with the hMSH2 positive score. The susceptibility of hMSH2-positive tumors to CDDP killing was significantly higher than that of hMSH2-negative tumors. Immunohistochemical results regarding hMSH2 are promising in the evaluation of the sensitivity of cancer cells to CDDP cytotoxicity and enable one to select patients for adjuvant chemotherapy for oral and oropharyngeal SCC.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7600053
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin, http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil, http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Mitomycin, http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein, http://linkedlifedata.com/resource/pubmed/chemical/Peplomycin, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0304-3835
pubmed:author	pubmed-author:FujiedaSS, pubmed-author:NodaII, pubmed-author:SaitoHH, pubmed-author:SugimotoCC, pubmed-author:SunagaHH, pubmed-author:TanakaNN, pubmed-author:TsuzukiHH
pubmed:issnType	Print
pubmed:day	23
pubmed:volume	132
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	37-44
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:10397451-Adult, pubmed-meshheading:10397451-Aged, pubmed-meshheading:10397451-Aged, 80 and over, pubmed-meshheading:10397451-Antineoplastic Agents, pubmed-meshheading:10397451-Carcinoma, Squamous Cell, pubmed-meshheading:10397451-Cisplatin, pubmed-meshheading:10397451-DNA-Binding Proteins, pubmed-meshheading:10397451-Doxorubicin, pubmed-meshheading:10397451-Female, pubmed-meshheading:10397451-Fluorouracil, pubmed-meshheading:10397451-Humans, pubmed-meshheading:10397451-Immunohistochemistry, pubmed-meshheading:10397451-Male, pubmed-meshheading:10397451-Middle Aged, pubmed-meshheading:10397451-Mitomycin, pubmed-meshheading:10397451-Mouth Neoplasms, pubmed-meshheading:10397451-MutS Homolog 2 Protein, pubmed-meshheading:10397451-Oropharyngeal Neoplasms, pubmed-meshheading:10397451-Peplomycin, pubmed-meshheading:10397451-Proto-Oncogene Proteins, pubmed-meshheading:10397451-Tumor Cells, Cultured
pubmed:year	1998
pubmed:articleTitle	Expression of hMSH2 correlates with in vitro chemosensitivity to CDDP cytotoxicity in oral and oropharyngeal carcinoma.
pubmed:affiliation	Department of Otorhinolaryngology, Fukui Medical University, Yoshida-gun, Japan. sfujieda@fmsrsa.fukui-med.ac.jp
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't