Source:http://linkedlifedata.com/resource/pubmed/id/10395220
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
1999-9-13
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| pubmed:abstractText |
Disturbances of the serotoninergic neutrotransmitter system have been implicated in the pathogenesis of mood disorders. A functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) has been recently reported to be associated with both unipolar and bipolar disorder. In this study, we investigated the possibility that the 5-HTTLPR might be associated with depressive symptomatology in a sample of mood disorder subjects. One hundred and thirty-two psychiatric inpatients affected by major depressive (n = 67) and bipolar (n = 65) disorder (DSM-IV) were assessed at admission by the Hamilton Depression Rating Scale (HAMD-21, divided into Core, Sleep, Activity, Psychic anxiety, Somatic anxiety and Delusion clusters) and were typed using PCR techniques. The only prior treatment permitted was low dose benzodiazepines (<5 mg diazepam or equivalent); no prior (<2 weeks) antidepressant or neuroleptic treatment was allowed. 5-HTTLPR variants were not associated with total depressive symptomatology as measured by HAMD. The short 5-HTTLPR variant was marginally associated with higher psychic anxiety scores (F = 7.11, d.f. = 1,262, P = 0.008). The association was stronger among bipolars and early onset subjects. 5-HTTLPR variants were not associated with the remaining symptom clusters. The upstream regulatory region of the serotonin transporter gene has not, therefore, a major influence on the depressive symptomatology in mood disorder subjects.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SLC6A4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1359-4184
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
4
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
280-3
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| pubmed:dateRevised |
2005-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10395220-Alleles,
pubmed-meshheading:10395220-Analysis of Variance,
pubmed-meshheading:10395220-Bipolar Disorder,
pubmed-meshheading:10395220-Carrier Proteins,
pubmed-meshheading:10395220-Chi-Square Distribution,
pubmed-meshheading:10395220-Chromosome Mapping,
pubmed-meshheading:10395220-Chromosomes, Human, Pair 17,
pubmed-meshheading:10395220-Depressive Disorder,
pubmed-meshheading:10395220-Female,
pubmed-meshheading:10395220-Humans,
pubmed-meshheading:10395220-Male,
pubmed-meshheading:10395220-Membrane Glycoproteins,
pubmed-meshheading:10395220-Membrane Transport Proteins,
pubmed-meshheading:10395220-Middle Aged,
pubmed-meshheading:10395220-Mood Disorders,
pubmed-meshheading:10395220-Nerve Tissue Proteins,
pubmed-meshheading:10395220-Polymerase Chain Reaction,
pubmed-meshheading:10395220-Polymorphism, Genetic,
pubmed-meshheading:10395220-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:10395220-Serotonin Plasma Membrane Transport Proteins
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| pubmed:year |
1999
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| pubmed:articleTitle |
Serotonin transporter gene (5-HTTLPR) is not associated with depressive symptomatology in mood disorders.
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| pubmed:affiliation |
Instituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric, Sciences, University of Milan School of Medicine, Italy. serretti.alessandro@mail.hsr.it
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| pubmed:publicationType |
Journal Article
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