Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-9-23
pubmed:abstractText
Hepatocellular damage has been reported as a consequence of 3,4-methylenedioxymethamphetamine (MDMA) intake. However, little is known about the cellular mechanisms involved. The present study was undertaken to evaluate the effects of MDMA on cell viability as well as free calcium levels ([Ca2+]i) in short-term cultured hepatocytes. Reduced glutathione (GSH), adenosine-5'-triphosphate (ATP) and lipid peroxidation were investigated to evaluate the toxic effect of MDMA, in vitro, using freshly isolated rat hepatocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0106-9543
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
234-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10395044-Adenosine Triphosphate, pubmed-meshheading:10395044-Animals, pubmed-meshheading:10395044-Calcium, pubmed-meshheading:10395044-Calcium Signaling, pubmed-meshheading:10395044-Cell Membrane, pubmed-meshheading:10395044-Cells, Cultured, pubmed-meshheading:10395044-Cytosol, pubmed-meshheading:10395044-Dose-Response Relationship, Drug, pubmed-meshheading:10395044-Egtazic Acid, pubmed-meshheading:10395044-Glutathione, pubmed-meshheading:10395044-L-Lactate Dehydrogenase, pubmed-meshheading:10395044-Lipid Peroxidation, pubmed-meshheading:10395044-Liver, pubmed-meshheading:10395044-Male, pubmed-meshheading:10395044-N-Methyl-3,4-methylenedioxyamphetamine, pubmed-meshheading:10395044-Rats, pubmed-meshheading:10395044-Rats, Wistar, pubmed-meshheading:10395044-Time Factors, pubmed-meshheading:10395044-Transaminases, pubmed-meshheading:10395044-Vasopressins
pubmed:year
1999
pubmed:articleTitle
3,4-Methylenedioxymethamphetamine (ecstasy)-induced hepatotoxicity: effect on cytosolic calcium signals in isolated hepatocytes.
pubmed:affiliation
Department of Pharmacology, University of Navarra, Pamplona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't