Source:http://linkedlifedata.com/resource/pubmed/id/10394126
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
1999-8-5
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| pubmed:abstractText |
The prognostic value of preoperative serum levels of CEA, CA 19-9 and CA 72-4 tumor markers was investigated in 153 patients resected for gastric cancer. The positivity rates for CEA, CA 19-9 and CA 72-4 were 20.9, 34.6 and 28.1%, respectively. Multiple logistic regression analysis for positive levels of tumor markers indicates that CEA positivity is significantly related to the depth of invasion (p < 0.005) and the presence of distant metastasis (p < 0. 05), CA 19-9 positivity is related to nodal involvement (p < 0.05) and the depth of invasion (p < 0.05), whereas CA 72-4 positivity is influenced by tumor size (p < 0.005) and noncurative surgery (p < 0. 05). Positive levels of each tumor marker were associated with a worse prognosis if compared with negative cases using univariate analysis. Multivariate analysis of curatively resected cases identified depth in gastric wall (p < 0.0001), nodal status (p < 0. 0005), and tumor location in the upper third (p < 0.05) as significant prognostic variables; CEA, CA 19-9 and CA 72-4 serum positivity did not reach statistical significance. However, when the positivity of the three markers was associated, a p value < 0.05 was observed. The analysis of survival curves stratified by tumor stage revealed that marker positivity significantly affects survival in stages I, II and IV (p < 0.05). The combined assay of CEA, CA 19-9 and CA 72-4 preoperative serum levels provides additional prognostic information in patients resected for gastric cancer; patients with preoperative positivity for one of these tumor markers should be considered at high risk of recurrence even in early stages of gastric carcinoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0030-2414
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
57
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
55-62
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10394126-Adult,
pubmed-meshheading:10394126-Aged,
pubmed-meshheading:10394126-Aged, 80 and over,
pubmed-meshheading:10394126-Antigens, Tumor-Associated, Carbohydrate,
pubmed-meshheading:10394126-CA-19-9 Antigen,
pubmed-meshheading:10394126-Carcinoembryonic Antigen,
pubmed-meshheading:10394126-Female,
pubmed-meshheading:10394126-Humans,
pubmed-meshheading:10394126-Logistic Models,
pubmed-meshheading:10394126-Male,
pubmed-meshheading:10394126-Middle Aged,
pubmed-meshheading:10394126-Multivariate Analysis,
pubmed-meshheading:10394126-Neoplasm Staging,
pubmed-meshheading:10394126-Predictive Value of Tests,
pubmed-meshheading:10394126-Prognosis,
pubmed-meshheading:10394126-Risk,
pubmed-meshheading:10394126-Stomach Neoplasms,
pubmed-meshheading:10394126-Survival Analysis
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| pubmed:year |
1999
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| pubmed:articleTitle |
Prognostic significance of CEA, CA 19-9 and CA 72-4 preoperative serum levels in gastric carcinoma.
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| pubmed:affiliation |
Second Department of Surgery, Istituto Policattedra di Scienze Chirurgiche, Università di Siena, Siena, Italia, Italy.
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| pubmed:publicationType |
Journal Article
|