| pubmed-article:10393986 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10393986 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:10393986 | lifeskim:mentions | umls-concept:C0010132 | lld:lifeskim |
| pubmed-article:10393986 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:10393986 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:10393986 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:10393986 | pubmed:dateCreated | 1999-8-26 | lld:pubmed |
| pubmed-article:10393986 | pubmed:abstractText | Corticotropin-releasing hormone (CRH) is a central regulator of the hormonal stress response, causing stimulation of corticotropin and glucocorticoid secretion. CRH is also widely believed to mediate stress-induced behaviors, implying a broader, integrative role for the hormone in the psychological stress response. Mice lacking the CRH gene exhibit normal stress-induced behavior that is specifically blocked by a CRH type 1 receptor antagonist. The other known mammalian ligand for CRH receptors is urocortin. Normal and CRH-deficient mice have an identical distribution of urocortin mRNA, which is confined to the region of the Edinger-Westphal nucleus, and is absent from regions known to mediate stress-related behaviors. Since the Edinger-Westphal nucleus is not known to project to any brain regions believed to play a role in anxiety-like behavior, an entirely different pathway must be postulated for urocortin in the Edinger-Westphal nucleus to mediate these behaviors in CRH-deficient mice. Alternatively, an unidentified CRH-like molecule other than CRH or urocortin, acting through the CRH receptors in brain regions believed to mediate stress-induced behaviors, may mediate the behavioral response to stress, either alone or in concert with CRH. | lld:pubmed |
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| pubmed-article:10393986 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10393986 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10393986 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10393986 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10393986 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10393986 | pubmed:author | pubmed-author:DunnA JAJ | lld:pubmed |
| pubmed-article:10393986 | pubmed:author | pubmed-author:MiczekK AKA | lld:pubmed |
| pubmed-article:10393986 | pubmed:author | pubmed-author:MajzoubJ AJA | lld:pubmed |
| pubmed-article:10393986 | pubmed:author | pubmed-author:SwiergielA... | lld:pubmed |
| pubmed-article:10393986 | pubmed:author | pubmed-author:BerridgeC WCW | lld:pubmed |
| pubmed-article:10393986 | pubmed:author | pubmed-author:DikkesPP | lld:pubmed |
| pubmed-article:10393986 | pubmed:author | pubmed-author:MugliaL JLJ | lld:pubmed |
| pubmed-article:10393986 | pubmed:author | pubmed-author:WeningerS CSC | lld:pubmed |
| pubmed-article:10393986 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10393986 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:10393986 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10393986 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10393986 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10393986 | pubmed:pagination | 8283-8 | lld:pubmed |
| pubmed-article:10393986 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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