Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1999-8-26
pubmed:abstractText
Corticotropin-releasing hormone (CRH) is a central regulator of the hormonal stress response, causing stimulation of corticotropin and glucocorticoid secretion. CRH is also widely believed to mediate stress-induced behaviors, implying a broader, integrative role for the hormone in the psychological stress response. Mice lacking the CRH gene exhibit normal stress-induced behavior that is specifically blocked by a CRH type 1 receptor antagonist. The other known mammalian ligand for CRH receptors is urocortin. Normal and CRH-deficient mice have an identical distribution of urocortin mRNA, which is confined to the region of the Edinger-Westphal nucleus, and is absent from regions known to mediate stress-related behaviors. Since the Edinger-Westphal nucleus is not known to project to any brain regions believed to play a role in anxiety-like behavior, an entirely different pathway must be postulated for urocortin in the Edinger-Westphal nucleus to mediate these behaviors in CRH-deficient mice. Alternatively, an unidentified CRH-like molecule other than CRH or urocortin, acting through the CRH receptors in brain regions believed to mediate stress-induced behaviors, may mediate the behavioral response to stress, either alone or in concert with CRH.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-10098506, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-1538563, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-1980834, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-2864480, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-3008937, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-3292920, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-3492730, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-513946, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-6181531, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-624070, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-6267699, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-6326264, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-6978997, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-7477349, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-7511978, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-7544278, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-7798937, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-7830793, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-7846062, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-78743, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8090722, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8182429, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8194481, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8221104, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8491091, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8597448, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8703220, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8816826, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8940412, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8949260, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-8971127, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9118349, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9118350, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9118356, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9137936, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9171885, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9189917, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9299637, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9372207, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9527535, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9535103, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9620773, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9628819, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9655498, http://linkedlifedata.com/resource/pubmed/commentcorrection/10393986-9886810
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8283-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:10393986-Animals, pubmed-meshheading:10393986-Mice, pubmed-meshheading:10393986-Pain, pubmed-meshheading:10393986-Pyrimidines, pubmed-meshheading:10393986-Fear, pubmed-meshheading:10393986-Learning, pubmed-meshheading:10393986-Pyrroles, pubmed-meshheading:10393986-Injections, Intraventricular, pubmed-meshheading:10393986-Female, pubmed-meshheading:10393986-Male, pubmed-meshheading:10393986-Electroshock, pubmed-meshheading:10393986-Reinforcement (Psychology), pubmed-meshheading:10393986-Cerebral Ventricles, pubmed-meshheading:10393986-Mice, Inbred Strains, pubmed-meshheading:10393986-Avoidance Learning, pubmed-meshheading:10393986-Motor Activity, pubmed-meshheading:10393986-Stress, Psychological, pubmed-meshheading:10393986-Conditioning, Operant, pubmed-meshheading:10393986-Crosses, Genetic, pubmed-meshheading:10393986-Corticotropin-Releasing Hormone
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