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rdf:type |
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|
lifeskim:mentions |
umls-concept:C0019116,
umls-concept:C0022889,
umls-concept:C0024501,
umls-concept:C0032043,
umls-concept:C0032961,
umls-concept:C0040048,
umls-concept:C0042149,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636
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pubmed:issue |
14
|
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pubmed:dateCreated |
1999-8-26
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pubmed:abstractText |
We employed a novel mouse line that expresses low levels of human tissue factor (TF) in the absence of murine TF to analyze the role of TF in gestation. Low-TF female mice had a 14-18% incidence of fatal postpartum uterine hemorrhage, suggesting that TF plays an important role in uterine hemostasis. Low-TF female mice mated with low-TF male mice had a 42% incidence of fatal midgestational hemorrhage (n = 41), whereas no fatal midgestational hemorrhages were observed in low-TF female mice mated with wild-type male mice (n = 43). Placentas of low-TF embryos from both low-TF and normal (+/-) TF females were abnormal and contained numerous maternal blood pools in the labyrinth. Placentas of TF null embryos surviving beyond embryonic day 10.5 exhibited similar defects. The mouse maternal-embryonic placental barrier consists of four cellular layers (layers I, II, and III and endothelial cells), where layer I lines the maternal lacunae. Comparison of TF-deficient placentas with control placentas by immunohistochemical and ultrastructural analyses revealed thinning of layer I and a reduction in the number of cellular contacts of layer I trophoblasts spanning the maternal blood space between adjacent trabeculae. These structural changes in low-TF and TF null placentas result in enlarged maternal lacunae, as determined by morphometric analysis, and placental hemorrhage, which leads to midgestational death of low-TF female mice. This study demonstrated that TF is required for uterine hemostasis and revealed an unexpected role of TF in the maintenance of the placental labyrinth.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-10094821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-1155360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-1566745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-1833852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-2169613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-2358199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-2652009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-3067973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-3194899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-7495298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-7521887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-7649481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-7743917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-7789261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-7876236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-8317556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-8574967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-8632823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-8686734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-8692802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-8779717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-8781413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-8900278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-8972001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9186598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9256442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9326649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9372105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9384381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9398442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9449688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9490735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9531578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9636195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9636196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10393961-9827803
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8138-43
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10393961-Animals,
pubmed-meshheading:10393961-Crosses, Genetic,
pubmed-meshheading:10393961-Female,
pubmed-meshheading:10393961-Hemostasis,
pubmed-meshheading:10393961-Humans,
pubmed-meshheading:10393961-Male,
pubmed-meshheading:10393961-Mice,
pubmed-meshheading:10393961-Mice, Knockout,
pubmed-meshheading:10393961-Placenta,
pubmed-meshheading:10393961-Pregnancy,
pubmed-meshheading:10393961-Puerperal Disorders,
pubmed-meshheading:10393961-Thromboplastin,
pubmed-meshheading:10393961-Uterine Hemorrhage,
pubmed-meshheading:10393961-Uterus
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pubmed:year |
1999
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pubmed:articleTitle |
Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation.
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pubmed:affiliation |
Departments of Immunology and Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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