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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1999-10-14
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pubmed:abstractText |
Lamina-associated polypeptide (LAP) 2, which directly interacts with B-type lamins and chromosomes, is an integral membrane protein specifically distributed along the inner nuclear membrane of the nuclear envelope. The chromatin- and lamin-binding activity of LAP2 suggests that LAP2 plays an important role in targeting mitotic vesicles to chromosomes and reorganizing the nuclear structure at the end of mitosis. Here I identified a LAP2 interacting protein, termed L2BP1 (LAP2 binding protein 1). The rat L2BP1 cDNA sequence is predicted to encode a protein of 89 amino acids which turns out to be a rat homolog of mouse and human BAF (Barrier-to-Autointegration Factor). L2BP1 is distributed diffusely throughout the nucleus in interphase cells. It is, however, highly concentrated at the chromosomes during the M-phase. Further, the L2BP1 binding domain of LAP2 overlaps its chromosome-binding region. These findings suggest that L2BP1 is a candidate mediator of LAP2-chromosome interaction at the end of mitosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BANF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Banf1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/lamina-associated polypeptide 2
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9533
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
112 ( Pt 15)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2485-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10393804-Amino Acid Sequence,
pubmed-meshheading:10393804-Animals,
pubmed-meshheading:10393804-Base Sequence,
pubmed-meshheading:10393804-Cell Line,
pubmed-meshheading:10393804-Cell Nucleus,
pubmed-meshheading:10393804-Chromatin,
pubmed-meshheading:10393804-Cloning, Molecular,
pubmed-meshheading:10393804-DNA, Complementary,
pubmed-meshheading:10393804-DNA-Binding Proteins,
pubmed-meshheading:10393804-Humans,
pubmed-meshheading:10393804-Membrane Proteins,
pubmed-meshheading:10393804-Mice,
pubmed-meshheading:10393804-Molecular Sequence Data,
pubmed-meshheading:10393804-Nuclear Proteins,
pubmed-meshheading:10393804-Rats,
pubmed-meshheading:10393804-Restriction Mapping,
pubmed-meshheading:10393804-Saccharomyces cerevisiae,
pubmed-meshheading:10393804-Sequence Alignment,
pubmed-meshheading:10393804-Sequence Homology, Amino Acid
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pubmed:year |
1999
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pubmed:articleTitle |
LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction.
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pubmed:affiliation |
Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya Japan, 464-8602.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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