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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-7-9
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pubmed:abstractText |
Ritonavir is a potent inhibitor of cytochrome P4503A4 that strongly increases saquinavir bioavailability. In this study we assessed the safety and antiretroviral efficacy of the combination of these two compounds in patients pretreated and receiving continued treatment with zidovudine and lamivudine who were protease inhibitor naive and who had a CD4 cell counts below 200/mm3.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0009-9236
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pubmed:author |
pubmed-author:ArvieuxCC,
pubmed-author:BazinCC,
pubmed-author:BellissantEE,
pubmed-author:CartierFF,
pubmed-author:ChauvinJ PJP,
pubmed-author:DelfraissyJ FJF,
pubmed-author:DohinEE,
pubmed-author:MichelerAA,
pubmed-author:RaffiFF,
pubmed-author:RenardII,
pubmed-author:RuffaultAA,
pubmed-author:SébilleVV
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
661-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10391672-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10391672-Adult,
pubmed-meshheading:10391672-Anti-HIV Agents,
pubmed-meshheading:10391672-CD4 Lymphocyte Count,
pubmed-meshheading:10391672-DNA, Viral,
pubmed-meshheading:10391672-Drug Administration Schedule,
pubmed-meshheading:10391672-Drug Resistance,
pubmed-meshheading:10391672-Drug Therapy, Combination,
pubmed-meshheading:10391672-Female,
pubmed-meshheading:10391672-Genotype,
pubmed-meshheading:10391672-HIV Protease Inhibitors,
pubmed-meshheading:10391672-Humans,
pubmed-meshheading:10391672-Lamivudine,
pubmed-meshheading:10391672-Male,
pubmed-meshheading:10391672-Middle Aged,
pubmed-meshheading:10391672-Mutation,
pubmed-meshheading:10391672-Pilot Projects,
pubmed-meshheading:10391672-Polymerase Chain Reaction,
pubmed-meshheading:10391672-Reverse Transcriptase Inhibitors,
pubmed-meshheading:10391672-Ritonavir,
pubmed-meshheading:10391672-Saquinavir,
pubmed-meshheading:10391672-Severity of Illness Index,
pubmed-meshheading:10391672-Time Factors,
pubmed-meshheading:10391672-Viral Load,
pubmed-meshheading:10391672-Zidovudine
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pubmed:year |
1999
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pubmed:articleTitle |
Safety and efficacy of ritonavir and saquinavir in combination with zidovudine and lamivudine.
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pubmed:affiliation |
Clinique des Maladies Infectieuses, Unité de Pharmacologie Clinique, Hôpital Universitaire, Rennes, France. Christian.Michelet@univ-rennes1.fr
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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