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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5424
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pubmed:dateCreated |
1999-7-26
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pubmed:databankReference |
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pubmed:abstractText |
Epithelia permit selective and regulated flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux between cells. Tight junctions constitute the barrier to paracellular conductance; however, little is known about the specific molecules that mediate paracellular permeabilities. Renal magnesium ion (Mg2+) resorption occurs predominantly through a paracellular conductance in the thick ascending limb of Henle (TAL). Here, positional cloning has identified a human gene, paracellin-1 (PCLN-1), mutations in which cause renal Mg2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These findings provide insight into Mg2+ homeostasis, demonstrate the role of a tight junction protein in human disease, and identify an essential component of a selective paracellular conductance.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
pubmed-author:Al-SabbanEE,
pubmed-author:BettinelliAA,
pubmed-author:CasariGG,
pubmed-author:ChoateK AKA,
pubmed-author:ColussiGG,
pubmed-author:LiftonR PRP,
pubmed-author:LoSS,
pubmed-author:McCredieDD,
pubmed-author:MilfordDD,
pubmed-author:PragaMM,
pubmed-author:Rodriguez-SorianoJJ,
pubmed-author:SanjadSS,
pubmed-author:SimonD BDB,
pubmed-author:VelazquezHH
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
285
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10390358-Amino Acid Sequence,
pubmed-meshheading:10390358-Calcium,
pubmed-meshheading:10390358-Chromosomes, Human, Pair 3,
pubmed-meshheading:10390358-Cloning, Molecular,
pubmed-meshheading:10390358-Female,
pubmed-meshheading:10390358-Genes, Recessive,
pubmed-meshheading:10390358-Homeostasis,
pubmed-meshheading:10390358-Humans,
pubmed-meshheading:10390358-Kidney Diseases,
pubmed-meshheading:10390358-Kidney Tubules,
pubmed-meshheading:10390358-Loop of Henle,
pubmed-meshheading:10390358-Magnesium,
pubmed-meshheading:10390358-Magnesium Deficiency,
pubmed-meshheading:10390358-Male,
pubmed-meshheading:10390358-Membrane Proteins,
pubmed-meshheading:10390358-Molecular Sequence Data,
pubmed-meshheading:10390358-Mutation,
pubmed-meshheading:10390358-Pedigree,
pubmed-meshheading:10390358-Physical Chromosome Mapping,
pubmed-meshheading:10390358-Tight Junctions
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pubmed:year |
1999
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pubmed:articleTitle |
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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