Source:http://linkedlifedata.com/resource/pubmed/id/10386938
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1999-9-23
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| pubmed:abstractText |
A series of 5H-thiazolo[3,2-a]pyrimidine derivatives 1 was studied with respect to the inhibition of 1S,3R-ACPD (10 microM)-stimulated GTP gamma35S binding on rat mGlu2 receptor transfected cell membranes. The influence of substituents at position 6 and 7 as well as the substitution pattern of the two phenyl-rings in position 2 and 5 on the activity is discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
7
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1573-6
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:10386938-Animals,
pubmed-meshheading:10386938-CHO Cells,
pubmed-meshheading:10386938-Cricetinae,
pubmed-meshheading:10386938-Excitatory Amino Acid Antagonists,
pubmed-meshheading:10386938-Kinetics,
pubmed-meshheading:10386938-Models, Chemical,
pubmed-meshheading:10386938-Pyrimidines,
pubmed-meshheading:10386938-Rats,
pubmed-meshheading:10386938-Structure-Activity Relationship
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists.
|
| pubmed:affiliation |
Pharma Division, Preclinical CNS Research, F. Hoffmann-La Roche Ltd., Basel. juergen.wichmann@roche.com
|
| pubmed:publicationType |
Journal Article
|