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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
11
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pubmed:dateCreated |
1999-9-23
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pubmed:abstractText |
We have developed a novel strategy for the preparation of tetrahedral transition state analogs for aspartic acid and metallo-proteases based upon the sulfonimidamide functional group. Our best alpha-des-amino dipeptide analog binds at least 100-fold tighter than the corresponding ground state structure (i.e., amide). A previously unpublished five-membered cyclic sulfonimidamide was also synthesized.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
|
pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
9
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1527-32
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
|
|
pubmed:year |
1999
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pubmed:articleTitle |
The sulfonimidamide as a novel transition state analog for aspartic acid and metallo proteases.
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|
pubmed:affiliation |
The Department of Medicinal Chemistry, The University of Kansas, Lawrence 66045, USA.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
